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Phenotypically sorted highly and weakly migratory triple negative breast cancer cells exhibit migratory and metastatic commensalism
BackgroundIntratumor heterogeneity is a well-established hallmark of cancer that impedes cancer research, diagnosis, and treatment. Previously, we...
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PRRG4 regulates mitochondrial function and promotes migratory behaviors of breast cancer cells through the Src-STAT3-POLG axis
BackgroundBreast cancer is the leading cause of cancer death for women worldwide. Most of the breast cancer death are due to disease recurrence and...
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Morphology, biochemistry and connectivity of Cluster N and the hippocampal formation in a migratory bird
The exceptional navigational capabilities of migrating birds are based on the perception and integration of a variety of natural orientation cues....
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Migratory pattern of zoonotic Toxocara cati and T. canis in experimentally infected pigs
BackgroundOver a billion people are infected with Toxocara canis or T. cati , the roundworms of dogs and cats. Historically, T. canis has been...
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Adipose Tissue and Bone Marrow-Derived Mesenchymal Stem Cells are not Really the Same: Investigating the Differences in Their Immunomodulatory, Migratory, and Adhesive Profile
Mesenchymal stem cells (MSCs) are the most widely used stem cells in regenerative medicine. They can be isolated from multiple sources, most commonly...
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A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4–ROS–NLRP3 pathway
BackgroundGiant pandas ( Ailuropoda melanoleuca ) are the obligate host of the parasitic roundworm Baylisascaris schroederi . The infection of giant...
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The metastatic capacity of high-grade serous ovarian cancer cells changes along disease progression: inhibition by mifepristone
BackgroundSimplistic two-dimensional (2D) in vitro assays have long been the standard for studying the metastatic abilities of cancer cells. However,...
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Impaired migratory phenotype of CD4+ T cells in Parkinson’s disease
Dysfunctions in the immune system appear implicated in both disease onset and progression of Parkinson’s disease (PD). Neurodegeneration observed in...
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Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells
BackgroundThe giant panda ( Ailuropoda melanoleuca ) is a well-known, rare and endangered species. Baylisascaris schroederi is a pathogenic ascarid....
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Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation
Glutathione (GSH), an abundant nonprotein thiol antioxidant, participates in several biological processes and determines the functionality of stem...
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Three Babesia species in Ixodes ricinus ticks from migratory birds in Sweden
BackgroundMigratory birds can cross geographical and environmental barriers and are thereby able to facilitate transmission of tick-borne pathogens...
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Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
Colchicine is an anti-inflammatory drug with a narrow therapeutic index. Its binding to tubulin prevents microtubule polymerization; however, little...
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Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy
IntroductionIncreasing evidence has revealed the key activity of protein disulfide isomerase A4 (PDIA4) in the endoplasmic reticulum stress (ERS)...
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CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer
BackgroundGastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have...
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22-O-(N-Boc-l-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial–mesenchymal transition in human lung cancer cells
The incidence of metastasis stage crucially contributes to high recurrence and mortality rate in lung cancer patients. Unfortunately, no available...
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Monitoring SARS-CoV-2 in the Wastewater and Rivers of Tapachula, a Migratory Hub in Southern Mexico
The COVID-19 pandemic has been monitored by applying different strategies, including SARS-CoV-2 detection with clinical testing or through...
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Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
T regulatory lymphocytes (Treg) expressing CCR5 exhibit strong suppression activity in various autoimmune disorders. However, there remains a lack of...
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Metagenomic analysis reveals the microbiome and resistome in migratory birds
BackgroundAntibiotic-resistant pathogens pose high risks to human and animal health worldwide. In recent years, the role of gut microbiota as a...
