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Association between depression and young-onset dementia in middle-aged women
BackgroundDementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (YOD), when...
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Middle Cerebral Artery Occlusion in Aged Animal Model
Stroke is a devastating brain injury resulting in high mortality and substantial loss of function, affecting >15 million people worldwide annually;...
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Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation
Understanding the biological effects of low-dose (<100 mGy) ionizing radiation (LDR) is technically challenging. We investigated age-dependent LDR...
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Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance
We recently reported accelerated cognitive decline in Europeans aged > 70 years with low circulating adropin levels. Adropin is a small, secreted...
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Optimizing intraluminal monofilament model of ischemic stroke in middle-aged Sprague–Dawley rats
Intraluminal monofilament model of middle cerebral artery occlusion (MCAO) is widely adopted for ischemic stroke; and Sprague–Dawley (SD) rats are...
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Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice
The early stages of ageing are a critical time window in which the ability to detect and identify precocious molecular and cognitive markers can make...
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Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people
Resistance training (RT) can increase the heat shock response (HSR) in the elderly. As middle-aged subjects already suffer physiological declines...
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The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats
BackgroundAging affects anxiety levels in rats while the pineal gland, via its hormone melatonin, could modulate their inherited life “clock.” The...
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Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice
Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life...
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The acute effect of passively assisted trunk stretching on central arterial stiffness and blood pressure in middle-aged to older adults
PurposeWe examined the effects of acute trunk stretching on central arterial stiffness and central and peripheral blood pressure in middle-aged to...
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Purpose in life promotes resilience to age-related brain burden in middle-aged adults
BackgroundDisease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable factors promoting...
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Habitual exercise influences carotid artery strain and strain rate, but not cognitive function in healthy middle-aged females
PurposeAging females are at risk of declining vascular and cognitive function. Exercise can augment both factors independently; however, the...
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Intense interval exercise induces greater changes in post-exercise metabolism compared to submaximal exercise in middle-aged adults
IntroductionHigh-intensity interval training (HIIT) and sprint interval training (SIT) consistently elevate post-exercise metabolism compared to...
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The relationship between social jetlag and subjective sleep quality: differences in young and middle-aged workers
Social jetlag is a recent problem that is associated with a wide range of issues in the context of modern life. However, differences in the effects...
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Levels of Brain-Derived Neurotrophic Factor (BDNF) and Ciliary Neurotrophic Factor (CNTF) in Blood and Tears of Young and Middle-Aged Patients with Vascular Cognitive Impairment and Depression
AbstractThe influence of neurotrophic factors on the development of vascular cognitive impairment (VCI) and depression has been investigated in a...
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Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet
We aimed to determine whether quercetin is capable of improving circadian rhythm and metabolism disorder under vitamin D-deficient condition....
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Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults: the FIT-AGEING study
The shed form of the Klotho protein (S-Klotho) is considered a biomarker of longevity, but it is still unknown whether the levels are related to...
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A prospective study of the association of weekend catch-up sleep and sleep duration with mortality in middle-aged adults
Health effects of weekend catch-up sleep (CUS) could differ depending on both the ability to obtain sufficient sleep during weekdays and amount of...
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The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults
BackgroundInsulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer’s clinical syndrome in epidemiologic studies...
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Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice
BackgroundObesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the development of...
