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Imaging Microtubule Network in Rodent Giant Glutamatergic Presynaptic Terminals
Increasing interest and evidence have pointed to the critical role of cytoskeleton elements such as microtubules or actin filaments in the regulation...
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Multiple pathways promote microtubule stabilization in senescent intestinal epithelial cells
Intestinal epithelial cells are critical for gastrointestinal homeostasis. However, their function declines during aging. The aging-related loss of...
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Microtubule acetylation dyshomeostasis in Parkinson’s disease
AbstractThe inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated...
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Microtubule-Targeting Agents Induce ROS-Mediated Apoptosis in Cancer
Cancer is a devastating disease worldwide and is characterized by elevated reactive oxygen species (ROS). ROS overproduction has been identified in...
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Centrosome, microtubule and DNA damage response
Centrosomes are the major microtubule-organizing center (MTOC), which are important cytoplasmic organelles regulating cell cycle, cell morphology,...
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Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration and microtubule stability
Phospholipase D2 (PLD2), a signaling protein, plays a central role in cellular communication and various biological processes. Here, we show that...
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A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics
ObjectiveHaploinsufficiency is widely accepted as the pathogenic mechanism of hereditary spastic paraplegias type 4 (SPG4). However, there are some...
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Microtubule disruption reduces metastasis more effectively than primary tumor growth
Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the...
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The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells
Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some...
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TM2, a novel semi-synthetic taxoid, exerts anti-MDR activity in NSCLC by inhibiting P-gp function and stabilizing microtubule polymerization
Taxane agents are of particular interest in non-small cell lung carcinomas (NSCLC) treatment, while multidrug resistance (MDR) mediated by...
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Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition
Ferroptosis is a form of regulated cell death resulting from iron accumulation and lipid peroxidation. Iron dyshomeostasis and peroxidation damage of...
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The Golgi apparatus is the main microtubule-organizing center in differentiating skeletal muscle cells
Studies in differentiating skeletal muscle cells in vitro have revealed that the microtubule-organizing center shifts from the centrosome to the...
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Microtubule Targeting Agents Induce ROS–Mediated Apoptosis in Cancer
Cancer is a devastating disease worldwide and is characterized by elevated reactive oxygen species (ROS). ROS overproduction has been identified in...
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CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or imaging tracers with utility for...
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Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin–p65 interaction
Neuroinflammation is one of the critical processes implicated in central nervous system (CNS) diseases. Therefore, alleviating neuroinflammation has...
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Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons
The establishment of polarity is an essential process in early neuronal development. Cdc42, a GTPase of the Rho family, is a key regulator of...
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Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents
BackgroundAnti-microtubule agents are widely used to treat ovarian cancers, but the efficacy is often compromised by drug resistance. We investigated...
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Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury
Spinal cord microcirculation plays an important role in maintaining the function of spinal cord neurons and other cells. Previous studies have...
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Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization
Endothelial fenestrae are the transcellular pores existing on the capillary walls which are organized in clusters referred to as sieve plates. They...
