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Transcriptomics-based liquid biopsy panel for early non-invasive identification of peritoneal recurrence and micrometastasis in locally advanced gastric cancer
BackgroundThis study aimed to develop a novel six-gene expression biomarker panel to enhance the early detection and risk stratification of...
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Multi-center study on predicting breast cancer lymph node status from core needle biopsy specimens using multi-modal and multi-instance deep learning
The objective of our study is to develop a deep learning model based on clinicopathological data and digital pathological image of core needle biopsy...
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Deep learning-based pathological prediction of lymph node metastasis for patient with renal cell carcinoma from primary whole slide images
BackgroundMetastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on...
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Chorioallantoic Membrane (CAM) and In Ovo Models as Potential Platforms for Testing Cancer Agents
The construction of clinically related models for cancer metastasis and anticancer testing plays a significant role in evidence-based translational...
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Chorioallantoic Membrane (CAM) and In Ovo Models as Potential Platforms for Testing Cancer Agents
The construction of clinically related models for cancer metastasis and anticancer testing plays a significant role in evidence-based translational...
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Sequential targeting of PARP with carboplatin inhibits primary tumour growth and distant metastasis in triple-negative breast cancer
BackgroundPatients with triple-negative breast cancer (TNBC) develop early recurrence. While PARP inhibitors (PARPi) have demonstrated potential in BRCA1/2...
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The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis
Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest recurrence and mortality rates, with the lungs being the...
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Preoperative short-course radiotherapy followed by consolidation chemotherapy for treatment with locally advanced rectal cancer: a meta-analysis
BackgroundThe addition of consolidation chemotherapy to preoperative short-course radiotherapy during the prolonged interval between the completion...
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Cancer Stem Cells and Metastasis
Metastasis stands to remain as the primary challenge in managing patients outcome. In recent years, research has shifted toward cancer stem cells...
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Metastasis and Cachexia
In this chapter, we will understand that malignant primary tumors become dangerous when angiogenesis allows their massive growth and in particular...
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Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients
BackgroundAbout 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance of early recurrence after radical resection, which is...
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Lymphangiogenesis: Lymphatic System and Lymph Nodes; Cancer Lymphangiogenesis and Metastasis
The lymphatic system is considered the major conduit for cancer metastasis. Two key recent developments have made cancer lymphangiogenesis and cancer...
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New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells
Metastasis is the primary cause of death in lung cancer patients. However, until now, effective drugs and intervention strategies for treating lung...
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Elevated FAM134B expression induces radiation-sensitive in hepatocellular carcinoma
BackgroundPrevious studies have shown that Family with sequence similarity 134 member B (FAM134B) was involved in the occurrence and development of...
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Zebrafish: A Model Organism to Understand Tumor Angiogenesis Mechanism
Tumor angiogenesis is the most crucial step in the progression of all types of cancers. Preexisted blood vessel vascularizes into new one through...
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The Microenvironment of Site-Specific Metastasis
Solid tumors can be visualized as an ecosystem composed of cancer and non-cancerous cells and their products, extra cellular matrix, metabolites, and...
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In Vitro and In Vivo Host Models of Metastasis
Metastasis is a complex multi-step process that typically occurs over years, making the process challenging to accurately model in the laboratory....
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CTCs/ctDNA and Brain Metastasis
An estimated 20–30% of all patients with cancer will develop brain metastasis, and this percentage increases at autopsy, with advanced stage and...
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Introduction on Cancerous Cells and Metastasis
The diffusion of cancer cells from the primary tumor site into a secondary organ of the body is called metastasis. Metastasis is a feature of...
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Risk model and factors for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer-a two-center cohort study
ObjectiveDue to inconsistency in neoadjuvant chemotherapy (NACT) response in advanced gastric cancer (GC), the indications remain the source of...
