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RNA Controls RNA
We know that microRNAs (miRNAs) are ubiquitous in all organisms. On the contrary, proteins are encoded in DNA on the genome and transcribed into...
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RNA Interference Ex Vivo
RNA interference (RNAi) is a widely used technique to regulate the expression of genes and proteins with a high degree of specificity that is not...
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Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents
ObjectiveMicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in...
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RNA polymerase II dynamics shape enhancer–promoter interactions
How enhancers control target gene expression over long genomic distances remains an important unsolved problem. Here we investigated...
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Protein–Protein and Protein–RNA Interaction Assays to Determine Similarity of INI1/SMARCB1 and TAR RNA in Binding to HIV-1 Integrase
INI1/SMARCB1 is a host protein that interacts with HIV-1 integrase (IN) and influences multiple stages of viral replication. IN is a viral enzyme...
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Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are...
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Nucleic Acids: DNA and RNA
Nucleic acids are biomacromolecules that exist naturally in all the living organisms, and play fundamental roles in many biological processes such as...
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Cancer-derived exosomal Alu RNA promotes colorectal cancer progression
Inflammation plays a crucial role in cancer progression, but the relevance of the inflammasome remains unclear. Alu RNA was the first endogenous...
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Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance
AbstractDiosmin is a flavonoid with promising anti-inflammatory and antioxidant properties. However, it has difficult physicochemical characteristics...
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Transcriptome dataset from Solanum lycopersicum L. cv. Micro-Tom; wild type and two mutants of INDOLE-ACETIC-ACID (SlIAA9) using long-reads sequencing oxford nanopore technologies
ObjectiveTomatoes are the most widely consumed fruit vegetable and are relatively easy to cultivate. However, an increase in temperature causes some...
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Critical Roles of Micro-RNAs in the Pathogenesis and Immunoregulation of Leishmania Infection
The genus Leishmania was first described in 1903 with the highly pathogenic species L. donovani, but several other pathogenic species have been...
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RNA-PAGE-Based Diagnosis of Viral Diseases
Regardless of low resources, many of the techniques have proven indispensable in every laboratory around the world, particularly in develo**...
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Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments
Although enhancers are central regulators of mammalian gene expression, the mechanisms underlying enhancer–promoter (E-P) interactions remain...
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Micro-inflammation related gene signatures are associated with clinical features and immune status of fibromyalgia
BackgroundFibromyalgia (FM) is a multifaceted disease. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been...
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Small Activating RNA Therapy for Angiogenesis
RNA activation has been known about for 15 years. In essence, it means activating the endogenous specific gene of cells by small RNA, which targets...
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Gene Expression in Synovium of Rotator Cuff Tear Patients Determined by RNA Sequencing
Rotator cuff tear (RCT) is a common shoulder disorder related to pain and dysfunction. However, the pathological mechanism of RCT remains unclear....
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Rapid Visualization of Gene Expression Using Chromogenic RNA In Situ Hybridization in African Killifish
Understanding the spatiotemporal pattern of genes involved in a specific biological process is critical for uncovering their organization,...
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Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma
BackgroundCircular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types...
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Blocking Abundant RNA Transcripts by High-Affinity Oligonucleotides during Transcriptome Library Preparation
BackgroundRNA sequencing has become the gold standard for transcriptome analysis but has an inherent limitation of challenging quantification of...
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Screening of four lysosome-related genes in sepsis based on RNA sequencing technology
PurposeScreening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy.
MethodsPeripheral blood samples...
