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Biomarkers of Antibiotic Toxicity: A Focus on Metronidazole
Toxicity arising from the use of antibiotics is a limiting factor in health care. Individualized drug therapy has been useful in reducing the...
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Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
Periodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this...
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Development of New PCR Protocols to Detect Genetic Diversity in the Metronidazole Metabolism Genes in Susceptible and Refractory Clinical Samples of Giardia duodenalis
PurposeInvestigating the genetic variation in thioredoxin reductase (TrxR) and nitroreductase (NR) genes in both treatment-resistant and -sensitive Gi...
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Association between perioperative prophylaxis with cefuroxime plus metronidazole or amoxicillin/clavulanic acid and surgical site infections in paediatric uncomplicated appendectomy: a Swiss retrospective cohort study
ObjectiveWe aimed to evaluate the association between post-appendectomy SSI rates and the two most commonly used regimens for perioperative...
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Metronidazole and Clindamycin
Metronidazole compound (1-[2-hydroxyethyl]-2-hydroxymethyl-5-nitroimidazole) is commonly used to treat anaerobic infections. It is the only one of...
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Impact of Formulation and Microneedle Length on Transdermal Metronidazole Permeation through Microneedle-Treated Skin
ObjectiveThis study aimed to determine the impact of formulation (gel vs cream) and microneedle characteristics (length, number) on permeation of...
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Detection of metronidazole resistance in Trichomonas vaginalis using uncultured vaginal swabs
Trichomonas vaginalis ( T. vaginalis ) is the most prevalent sexually transmitted infection (STI) globally. Metronidazole is the drug of choice for...
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Biomarkers of Antibiotic Toxicity: A Focus on Metronidazole
Toxicity arising from the use of antibiotics is a limiting factor in health care. Individualized drug therapy has been useful in reducing the...
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The potential liver injury induced by metronidazole-provoked disturbance of gut microbiota: modulatory effect of turmeric supplementation
It has been reported that the gut-liver axis and intestinal microbiome contribute crucially to different liver diseases. So, targeting this...
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Bioequivalence Evaluation of Topical Metronidazole Products Using Dermal Microdialysis in New Zealand Rabbits
Comparative assessment of cutaneous pharmacokinetics (cPK) by dermal microdialysis (dMD) appears to be suitable to evaluate the bioequivalence (BE)...
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Heteroresistance to clarithromycin and metronidazole in patients with a Helicobacter pylori infection: a systematic review and meta-analysis
BackgroundAntimicrobial resistance of H. pylori can lead to treatment failure. Importantly, several studies have reported on heteroresistance, i.e....
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Association of antimicrobial perioperative prophylaxis with cefuroxime plus metronidazole or amoxicillin/clavulanic acid and surgical site infections in colorectal surgery
ObjectiveTo compare intravenous (IV) amoxicillin/clavulanic acid (A/CA) to IV cefuroxime plus metronidazole (C + M) for preventing surgical site...
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Real-world comparison of fidaxomicin versus vancomycin or metronidazole in the treatment of Clostridium difficile infection: a systematic review and meta-analysis
PurposeThere is a lack of real-world evidence of the comparative effectiveness of fidaxomicin versus vancomycin or metronidazole for treating...
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Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study—phase III
BackgroundCesarean section (CS) is the most frequently performed surgery in the United States. Compared to vaginal delivery, CS has a higher risk of...
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The antimicrobial peptides LL-37, KR-20, FK-13 and KR-12 inhibit the growth of a sensitive and a metronidazole-resistant strain of Trichomonas vaginalis
The parasite Trichomonas vaginalis is the aetiologic agent of trichomoniasis, the most common non-viral sexually transmitted disease worldwide. This...
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Antimicrobial Efficacy Evaluations of Metronidazole against Clostridioides difficile Infection using Fecal Pharmacokinetic and Pharmacodynamic Analyses
ObjectivesThe pharmacokinetics/pharmacodynamics (PK/PD) characteristics of metronidazole (MNZ) in Clostridioides difficile infection (CDI) remain...
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Antitrichomonal activity of metronidazole-loaded lactoferrin nanoparticles in pigeon trichomoniasis
In recent years, increasing attention has been paid to the novel drug delivery systems to reduce the dose of the drug and avoid side effects....
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Higher amoebic and metronidazole resistant forms of Blastocystis sp. seen in schizophrenic patients
BackgroundBlastocystis sp. is one of the most common colonisers of the intestinal tract that demonstrate strong interaction with accompanying gut...
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Distribution of genotypes in relation to metronidazole susceptibility patterns in Trichomonas vaginalis isolated from South African pregnant women
Reports on metronidazole resistance of Trichomonas vaginalis strains have been on the increase. This study investigated the in vitro metronidazole...
