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Study on genotype and phenotype of novel CYP2D6 variants using pharmacokinetic and pharmacodynamic models with metoprolol as a substrate drug
To investigate the pharmacokinetic and pharmacodynamic profiles of volunteers carrying CYP2D6 genotypes with unknow metabolic phenotypes, a total of...
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Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway
PurposeTo compare the co-prescription of metoprolol and potent CYP2D6-inhibiting antidepressants before and during a 10-year period after...
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Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction
Despite the presence of clinical guidelines recommending that β-blocker treatment be initiated early after reperfused myocardial infarction (RMI),...
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Metoprolol Protects Against Arginine Vasopressin-Induced Cellular Senescence in H9C2 Cardiomyocytes by Regulating the Sirt1/p53/p21 Axis
Cardiomyocyte senescence is involved in the pathological mechanism of cardiac diseases. Metoprolol is a β1 receptor blocker used for the treatment of...
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Synthesis, Characterization, In Silico Analysis, and Pharmacological Evaluation of Metoprolol-Modified Saccharide Conjugates for Cardiovascular Targeting
Targeted drug delivery to selective cell has emerged as one of the most significant areas of biomedical engineering research today, so to optimize...
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Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites
IntroductionMetoprolol succinate is a long-acting beta-blocker prescribed for the management of hypertension (HTN) and other cardiovascular diseases....
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Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea
Obstructive sleep apnea (OSA) is closely associated with central nervous system diseases and could lead to autonomic nerve dysfunction, which is...
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Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study
PurposeThe β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme...
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Characterization of critical parameters using an air–liquid interface model with RPMI 2650 cells for permeability studies of small molecules
The field of nasal drug delivery gained enormously on interest over the past decade. Performing nasal in vivo studies is expensive and...
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Drug consumption in German cities and municipalities during the COVID-19 lockdown: a wastewater analysis
Analysis of illicit drugs, medicines, and pathogens in wastewater is a powerful tool for epidemiological studies to monitor public health trends. The...
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β1- and β1/β2-adrenergic receptor antagonists block 6-nitrodopamine-induced contractions of the rat isolated epididymal vas deferens
6-Nitrodopamine (6-ND) is an endogenous modulator of the contractility in the rat isolated epididymal vas deferens (RIEVD) and considered to be the...
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The role of the peripheral and central adrenergic system in the construction of the subjective emotional experience of panic
RationaleAlthough the study of emotions can look back to over 100 years of research, it is unclear which information the brain uses to construct the...
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The role of beta-adrenoreceptors in postoperative ileus in rats
The aim of the research was to evaluate the influence of antagonists of specific beta-adrenergic receptor subtypes on bowel motility following...
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Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets
Early intervention and short-duration treatments with antibiotics in premature infants are reported to reduce the incidence of necrotizing...
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Evidence on the Impact of Pharmacogenetics to Treat and Manage Cardiovascular Diseases
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Effective medications for the treatment of cardiovascular...
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Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
BackgroundDiabetes Mellitus (DM) is a prominent health care issue worldwide. One of the most prevalent comorbidities of DM is cardiovascular disease...
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Adrenergic Receptors in the Mechanism of Regulation of Mitochondrial and Cytoplasmic Enzymes of Cardiomyocytes by Catecholamines
We studied the role of adrenoceptors in the regulation of activity of mitochondrial and cytoplasmic enzymes in cardiomyocytes by catecholamines and...
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Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value
The main objective was to compare the meaning of soluble angiotensin-converting enzyme-2 (sACE2) plasma levels modulation on the prognosis of two...
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Stage IV renal cell carcinoma achieves pathologic complete response after two ipilimumab plus nivolumab courses despite severe immune-related adverse events: a case report
BackgroundIpilimumab (Ipi) plus nivolumab (Nivo) is the recommended first-line treatment for renal cell carcinoma (RCC). This report describes a case...
