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Metabolic signature of methylone in primary mouse hepatocytes, at subtoxic concentrations
Methylone (3,4-methylenedioxymethcathinone) is one of the most popular new psychoactive drugs worldwide. Although advertised as a safe drug, its use...
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Pharmacokinetics of Synthetic Cathinones Found in Bath Salts in Mouse Brain and Plasma Using High-Pressure Liquid Chromatography–Tandem Mass Spectrometry
Background and ObjectivesApproximately 10 years ago, “bath salts” became popular as legal alternatives to the psychostimulants cocaine and the...
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Dopaminergic Effects of Major Bath Salt Constituents 3,4-Methylenedioxypyrovalerone (MDPV), Mephedrone, and Methylone Are Enhanced Following Co-exposure
Designer drug mixtures popularized as “bath salts” often contain the synthetic cathinones 3,4 methylenedioxypyrovalerone (MDPV), mephedrone, and...
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Relative reinforcing effects of dibutylone, ethylone, and N-ethylpentylone: self-administration and behavioral economics analysis in rats
RationaleFollowing the emergence of methylone as one of the most popular synthetic cathinones, this group of novel psychoactive substance with names...
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Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Sco** Review
The cardiotoxic effects of synthetic cathinones remain largely unknown. In this study, we present two cases, a case series and a sco** review, to...
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Behavioral economic analysis of the reinforcing effects of “bath salts” mixtures: studies with MDPV, methylone, and caffeine in male Sprague-Dawley rats
Rationale“Bath salts” preparations often contain combinations of synthetic cathinones (e.g., 3,4-methylenedioxymethcathinone [methylone],...
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Target Analysis of NPS in Oral Fluid
The need to identify and quantify a growing number of NPS represents a crucial challenge for toxicological and forensic purposes. Among biological...
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Target Analysis of Synthetic Cathinones in Blood and Urine
Synthetic cathinones are new psychoactive substances which act as central nervous system stimulants with mixed sympathomimetic activity. In the last...
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A systematic review and meta-analysis of synthetic cathinone use and psychosis
RationaleSynthetic cathinones (SC), commonly referred to as “bath salts”, are stimulants resembling the natural alkaloid cathinone found in the khat ...
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Target Analysis of NPS in Alternative Matrix Hair
An overview of the detection of novel psychoactive substances (NPS) and their detection in hair is provided. The overview focuses on the major NPS...
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Target Analysis of NPS in Other Alternative Matrices: Dried Blood Spots and Meconium
Dried Blood Spots (DBS) and meconium represent valid alternative matrices for detection of New Psychoactive Substances (NPS), both having the...
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An updated review on synthetic cathinones
Cathinone, the main psychoactive compound found in the plant Catha edulis Forsk. (khat), is a β-keto analogue of amphetamine, sharing not only the...
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Drugs of Abuse: Trends and Advanced Analytical Methods
Abuse of drugs is correlated with various medical, behavioral, psychological, spiritual, financial, social, family, and legal concerns and profoundly...
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Simultaneous multi-targeted forensic toxicological screening in biological matrices by MRM-IDA-EPI mode
The toxicologist ascertains drug assumptions in case of paediatric intoxications and death for overdose. The analytical approach consists of...
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The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates
RationaleSynthetic cathinones continue to emerge in recreational drug markets worldwide. 1-(1,3-Benzodioxol-5-yl)-2-(methylamino)butan-1-one...
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A review of the influence of functional group modifications to the core scaffold of synthetic cathinones on drug pharmacokinetics
RationaleThe synthetic cathinones are a class of designer drugs of abuse that share a common core scaffold. The pharmacokinetic profiles of the...
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Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of β-keto amphetamines-related neurotoxicity
Autophagy has an essential role in neuronal homeostasis and its dysregulation has been recently linked to neurotoxic effects of a growing list of...
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Adverse outcome pathways induced by 3,4-dimethylmethcathinone and 4-methylmethcathinone in differentiated human SH-SY5Y neuronal cells
Cathinones (β-keto amphetamines), widely abused in recreational settings, have been shown similar or even worse toxicological profile than classical...
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The neurobehavioral effects of the designer drug naphyrone – an experimental investigation with pharmacokinetics and concentration/effect relationship in mice
RationaleThe recreational use of naphyrone, a potent synthetic cathinone with a pyrovalerone structure, has raised questions about possible...
