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Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study
BackgroundMetabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5...
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Metabotropic glutamate group II receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats
RationaleAfter a history of intermittent cocaine intake, rats develop patterns of drug use characteristic of substance use disorder. The dorsal...
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Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats
The underlying mechanisms of opioid-induced hyperalgesia (OIH) remain unclear. Herein, we found that the protein expression of metabotropic glutamate...
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Rare recurrent copy number variations in metabotropic glutamate receptor interacting genes in children with neurodevelopmental disorders
BackgroundNeurodevelopmental disorders (NDDs), such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are...
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Live FRET-FLIM Imaging to Study Metabotropic Signaling via the NMDA Receptor
Until recently, NMDA receptor (NMDAR) functions have been attributed to its ability to conduct calcium ions. However, growing evidence demonstrates...
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Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage
DNA damaging agents are used as chemotherapeutics in many cancers, including hepatocellular carcinoma (HCC). However, they are associated with...
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Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
RationaleAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and restricted/stereotyped...
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Surface Glutamate Receptor Nanoscale Organization with Super-Resolution Microscopy (dSTORM)
Glutamate receptors mediate the majority of excitatory transmission in the central nervous system. Recent developments in super-resolution...
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Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine
The aim of this study is to investigate the changes in expression of metabotropic glutamate (Glu) receptor subtype 1 (mGluR1), a key molecule...
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PET Imaging of Type 5 Metabotropic Glutamate Receptors
This chapter describes the use of positron emission tomography (PET) for in vivo imaging of brain regional type 5 metabotropic glutamate (mGlu5)...
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Ketamine and Other Glutamate Receptor Antagonists As Fast-Actin
The glutamate hypothesis of depression was prominently emerging in this decade. Evidence has shown that low-dose ketamine infusion or intranasal...
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Co-labeling of Neuronal Cells Using DiI Neuronal Filling and Immunohistochemistry to Explore Metabotropic Glutamate Receptor Expression
Neuronal morphology, including microarchitecture, can provide insightful information regarding neuronal physiology. Dendritic spines are highly...
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Metabotropic group II glutamate receptors mediate cue-triggered increases in reward-seeking behaviour
RationaleReward-associated cues can invigorate reward-seeking actions via Pavlovian-to-instrumental transfer (PIT). Glutamatergic neurotransmission...
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Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease
BackgroundMicroglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However,...
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Glutamate, Glutamatergic Drugs and Schizophrenia
Over the past two decades, increasing evidence from preclinical and human studies supports a major role of glutamatergic dysfunction in the...
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The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats
RationaleCocaine use disorder (CUD) is a brain disorder for which there is no Food and Drug Administration-approved pharmacological treatment....
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A pilot study on glutamate receptor and carrier gene variants and risk of childhood autism spectrum
Imbalanced glutamate signaling has been implicated in the development of autism spectrum disorder (ASD). This case-control study was to examine...
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Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation
RationaleReward-associated cues can trigger incentive motivation for reward and invigorate reward-seeking behaviour via Pavlovian-to-instrumental...
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Glutamate and Neurodegeneration in the Retina
L-glutamate is a neurotransmitter throughout the various levels of retinal neurones (photoreceptors, bipolar cells, ganglion cells) and acts at a...
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Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand
Metabotropic glutamate receptor subtype 2 (mGlu2) is a G-protein-coupled receptor and involved in the physiopathology of several major mental...