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Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
BackgroundB vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several...
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Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
BackgroundType 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the...
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Lipidome of mammographic breast density in premenopausal women
BackgroundHigh mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD...
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Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions
Mammalian cells utilize glucose as a primary carbon source to produce energy for most cellular functions. However, the bioenergetic homeostasis of...
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Comprehensive blood metabolomics profiling of Parkinson’s disease reveals coordinated alterations in xanthine metabolism
Parkinson’s disease (PD) is a highly heterogeneous disorder influenced by several environmental and genetic factors. Effective disease-modifying...
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Rare and common genetic determinants of metabolic individuality and their effects on human health
Garrod’s concept of ‘chemical individuality’ has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput...
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Untargeted serum metabolomic profiles and breast density in young women
Purpose of the studyBreast density is an established risk factor for breast cancer. However, little is known about metabolic influences on breast...
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Carbonic anhydrase IX and acid transport in cancer
Alterations in tumour metabolism and acid/base regulation result in the formation of a hostile environment, which fosters tumour growth and...
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Childhood adiposity, serum metabolites and breast density in young women
BackgroundChildhood adiposity is inversely associated with young adult percent dense breast volume (%DBV) and absolute dense breast volume (ADBV),...
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Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer
BackgroundNaturally occurring germline gene deletions (KO) represent a unique setting to interrogate gene functions. Complete deletions and...
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Methodological and analytical considerations for intra-operative microdialysis
BackgroundMicrodialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in...
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XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner
BackgroundDifferences in male vs. female immune responses are well-documented and have significant clinical implications. While the immunomodulatory...
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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood...
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Association between human blood metabolome and the risk of breast cancer
BackgroundBreast cancer is the most common cancer among women with limited treatment options. To identify promising drug targets for breast cancer,...
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An integrated multi-omic approach demonstrates distinct molecular signatures between human obesity with and without metabolic complications: a case–control study
ObjectivesTo examine the hypothesis that obesity complicated by the metabolic syndrome, compared to uncomplicated obesity, has distinct molecular...
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Recommended Resources for Biomarkers in Diabetes: Methods, Discoveries, and Applications
Diabetes mellitus is a treatable disease characterized by persistent hyperglycemia. Its prevalence is spiraling out of control, resulting in...
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Microbiome and metabolome features of the cardiometabolic disease spectrum
Previous microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes,...
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Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS
BackgroundAcute respiratory distress syndrome (ARDS), a life-threatening condition during critical illness, is a common complication of COVID-19. It...
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Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of...
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Blood metabolites and chronic kidney disease: a Mendelian randomization study
BackgroundHuman blood metabolites have demonstrated close associations with chronic kidney disease (CKD) in observational studies. Nonetheless, the...
