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Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival
The epigenetic changes associated with melanoma progression to advanced and metastatic stages are still poorly understood. To shed light on the CpG...
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Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion
BackgroundThe mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has...
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Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice
Recent pan-cancer genomic analyses have identified numerous oncogenic driver mutations that occur in a cell-type and tissue-specific distribution....
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BLOC1S5 pathogenic variants cause a new type of Hermansky–Pudlak syndrome
PurposeHermansky–Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, excessive bleeding, and often additional symptoms. Variants in...
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Delineating three-dimensional behavior of uveal melanoma cells under anchorage independent or dependent conditions
BackgroundAlthough rare, uveal melanoma (UM) is a life-threatening malignancy. Understanding its biology is necessary to improve disease outcome....
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Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea
BackgroundMicrobes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that mediate microbe-microbe...
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Pitfalls in Cutaneous Melanoma Diagnosis and the Need for New Reliable Markers
Cutaneous melanoma is one of the most aggressive forms of skin cancer, with the development of advanced stage disease resulting in a high rate of...
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CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth
BackgroundThough the CXCR2 chemokine receptor is known to play a key role in cancer growth and response to therapy, a direct link between expression...
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Molecular mimicry and cancer vaccine development
BackgroundThe development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which...
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CD28/PD1 co-expression: dual impact on CD8+ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response
BackgroundImmune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most...
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In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of Twenty-First Century: Exploitation of Peptides as Carriers for Their Intracellular Delivery
In vitro-transcribed mRNAs (IVT-mRNAs) are easily and rapidly designed in vitro synthesized RNA molecules. After their intracellular delivery through...
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Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade
BackgroundTumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by...
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Simultaneous endocrine expression and loss of melanoma markers in malignant melanoma metastases, a retrospective analysis
Malignant melanoma metastases are chameleons of histopathology. In 4 primary malignant melanomas and 20 melanoma metastases expression of S-100,...
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Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis
BackgroundWe have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This...
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Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma
BackgroundSystemic therapy for metastatic clear cell sarcoma (CCS) bearing EWSR1-CREB1/ATF1 fusions remains an unmet clinical need in children,...
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Simultaneous diagnosis of liver PEComa in a family with known Li–Fraumeni syndrome: a case report
BackgroundLi–Fraumeni syndrome (LFS) is an autosomal dominant hereditary disease. It is associated with the loss of function of the p53 protein and...
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Two New Species of Annulotrema (Monogenea: Dactylogyridae) Gill Parasites of Brycinus macrolepidotus Valenciennes, 1849 from Nyong River, Cameroon
PurposeResearch on gill monogeneans of Characiform has made it possible to find two new species belonging to the genus Annulotrema . The purpose of...
