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Mechanistic interplay of different mediators involved in mediating the anti-depressant effect of isoflavones
Depression is one of the most prevalent severe CNS disorders, which negatively affects social lives, the ability to work, and the health of people....
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The mediating effect of perceived stress on the relationship between big five personality traits and suboptimal health status in Chinese population: a nationwide survey in the framework of predictive, preventive, and personalized medicine
BackgroundThe effects of psychological factors on suboptimal health status (SHS) have been widely described; however, mechanisms behind the complex...
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Deciphering the effect of phytosterols on Alzheimer’s disease and Parkinson’s disease: the mediating role of lipid profiles
BackgroundStudies have suggested that blood circulating phytosterols, plant-derived sterols analogous to cholesterol, were associated with blood...
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The mediating role of meaning in life between experiential avoidance and death anxiety among cancer patients: a cross-sectional study
BackgroundDeath anxiety is thought to cause a range of mental disorders among cancer patients, which may affect their mental health and even quality...
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Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function
DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics...
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The mediating role of cognitive distortions in the relationship between problematic social media use and self-esteem in youth
Self-esteem expresses the individual's approach to himself and affects the whole life in terms of mental health. Another important factor affecting...
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Multifaceted roles of flavonoids mediating plant-microbe interactions
Plant-microbe interactions dynamically affect plant growth, health, and development. The mechanisms underpinning these associations are—to a large...
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ZC3H13 Accelerates Keloid Formation by Mediating N6-methyladenosine Modification of HIPK2
Keloids are fibroproliferative skin disorders caused by the improper healing of wounded skin. A growing body of evidence suggests the involvement of...
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Psychological capital and alienation among patients with COVID-19 infection: the mediating role of social support
BackgroundCOVID-19 infection continues all over the world, causing serious physical and psychological impacts to patients. Patients with COVID-19...
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The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: a prospective cohort study
BackgroundChildhood overweight/obesity is a global public health concern. It is important to identify its early-life risk factors. Maternal poor...
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The NLRP3 inflammasome: a vital player in inflammation and mediating the anti-inflammatory effect of CBD
BackgroundThe NLRP3 inflammasome is a vital player in the emergence of inflammation. The priming and activation of the NLRP3 inflammasome is a major...
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Interplay of chronic obstructive pulmonary disease and colorectal cancer development: unravelling the mediating role of fatty acids through a comprehensive multi-omics analysis
BackgroundChronic obstructive pulmonary disease (COPD) patients often exhibit gastrointestinal symptoms, A potential association between COPD and...
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USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis
The aim of this study is to explore the function of USP14 on the sensitivity of retinoblastoma (RB) to cisplatin (DDP) and the underlying mechanism....
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Propofol Ameliorates Spinal Cord Injury Process by Mediating miR-672-3p/TNIP2 Axis
Propofol has been found to have a protective effect against spinal cord injury (SCI). However, the underlying molecular mechanism of propofol...
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The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study
BackgroundStressful events and meaning-making toward them play an important role in adolescents’ life and growth. However, ignoring positive...
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P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC
BackgroundN7-methylguanosine (m7G) modification is, a more common epigenetic modification in addition to m6A modification, mainly found in mRNA...
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The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project
BackgroundThe causal pathway between high education and reduced risk of gastric cancer (GC) has not been explained. The study aimed at evaluating the...
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FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury
Current therapies are of limited efficacy in cerebral ischemia/reperfusion (I/R) injury. Based on the important role of oxidative stress in cerebral...
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YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance
ObjectiveGastric cancer (GC) stands as a prevalent and deadly global malignancy. Despite its role as a preoperative neoadjuvant therapy, Apatinib’s...
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Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway
Cholangiocarcinoma is a highly aggressive malignant tumor disease with the increasing incidence and mortality. It’s urgent to identify specific...
