Search
Search Results
-
-
-
Determination of the median lethal dose of zinc gluconate in mice and safety evaluation
BackgroundZinc Gluconate (ZG) is a safe and effective supplement for zinc. However, there is limited research on the optimal dosage for intravenous...
-
-
Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have obvious advantages over MSC therapy. But the strong procoagulant properties of...
-
Lethal and sublethal impacts of membrane-fed ivermectin are concentration dependent in Anopheles coluzzii
BackgroundIvermectin is a well-tolerated anthelminthic drug with wide clinical and veterinary applications. It also has lethal and sublethal effects...
-
AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia
Pseudomonas aeruginosa poses a significant threat to immunocompromised individuals and those with cystic fibrosis. Treatment relies on antibiotics,...
-
YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge
Ebola virus (EBOV) and related filoviruses such as Sudan virus (SUDV) threaten global public health. Effective filovirus vaccines are available only...
-
Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning
IntroductionCyanide exposure can occur in various settings such as industry and metallurgy. The primary mechanism of injury is cellular hypoxia from...
-
Sub-lethal exposure to chlorfenapyr reduces the probability of develo** Plasmodium falciparum parasites in surviving Anopheles mosquitoes
BackgroundPyrethroid resistance in the key malaria vectors threatens the success of pyrethroid-treated nets. To overcome pyrethroid resistance,...
-
Modifiable risk factors for subsequent lethal prostate cancer among men with an initially negative prostate biopsy
BackgroundPreviously suggested modifiable risk factors for prostate cancer could have resulted from detection bias because diagnosis requires a...
-
ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys
Nipah virus (NiV) is a highly pathogenic and re-emerging virus, which causes sporadic but severe infections in humans. Currently, no vaccines against...
-
A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated...
-
Principles of EC50, ED50, pD2 and pA2 Values of Drugs
The effects of most drugs depend on the dose that is provided to the subject. In line with this, we have a concept called “dose descriptors”, which...
-
Maximum Tolerated Dose (MTD) Studies in Drug Toxicology Assessments
In order to transition a new chemical entity (NCE) from the discovery arena into nonclinical development and potentially the clinic, a comprehensive...
-
Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge
SARS-CoV-2 is a viral respiratory pathogen responsible for the current global pandemic and the disease that causes COVID-19. All current WHO approved...
-
Application of median lethal concentration (LC50) of pathogenic microorganisms and their antigens in vaccine development
ObjectiveLack of ideal mathematical models to qualify and quantify both pathogenicity, and virulence is a dreadful setback in development of new...
-
A randomized phase II study of full dose gemcitabine versus reduced dose gemcitabine and nab-paclitaxel in vulnerable patients with non-resectable pancreatic cancer (DPCG-01)
BackgroundAccording to current evidence, the best treatment for fit patients with non-resectable pancreatic cancer (PC) is combination chemotherapy,...
-
Dose escalation in oropharyngeal cancer: a comparison of simultaneous integrated boost and brachytherapy boost
BackgroundLocal recurrence is the most common pattern of failure in head and neck cancer. It can therefore be hypothesised that some of these...
-
Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers
BackgroundSomatic copy number alterations are a hallmark of cancer that offer unique opportunities for therapeutic exploitation. Here, we focused on...
