Search
Search Results
-
Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture
Renal micropuncture, which requires the direct access to the renal tubules, has for long time been the technique of choice to measure the single...
-
Glomerular Filtration and Renal Blood Flow
The first step in urine formation is the production of an ultrafiltrate of plasma through the process glomerular filtration. Daily, in a healthy...
-
When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?
AimsWhether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation...
-
Changes in estimated glomerular filtration rate in patients administered proton pump inhibitors: a single-center cohort study
Proton pump inhibitor (PPI) use may be associated with renal dysfunction. Renal dysfunction in PPI users requires evaluation of development and...
-
Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism
Background and ObjectivesAcute inflammation caused by infections or sepsis can impact pharmacokinetics. We used a model-based analysis to evaluate...
-
Pharmacokinetics of Gentamicin Components C1, C1a, and C2/C2a/C2b and Subsequent Decline in Glomerular Filtration Rate in Neonates
Gentamicin is a commonly used antibiotic in neonates. Its components C1, C1a, C2, C2a, and C2b may have different nephrotoxic potential. We aimed to...
-
Failure to predict amikacin elimination in critically ill patients with cancer based on the estimated glomerular filtration rate: applying PBPK approach in a therapeutic drug monitoring study
Abstract PurposeThe aim of this work was to integrate the Therapeutic Drug Monitoring (TDM) with the model-informed precision dosing (MIPD) approach,...
-
Metabolically healthy obesity is associated with higher risk of both hyperfiltration and mildly reduced estimated glomerular filtration rate: the role of serum uric acid in a cross-sectional study
BackgroundThe impact of metabolically healthy obesity (MHO) on kidney dysfunction remains debatable. Moreover, few studies have focused on the early...
-
Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients
PurposeEstimated glomerular filtration rate (eGFR) equations reflect kidney function imprecisely. We aimed to describe whether iohexol-based GFR or...
-
A real or apparent decrease in glomerular filtration rate in patients using olaparib?
PurposeOlaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for ovarian and metastatic breast cancer. Increased serum creatinine...
-
Open-Source System for Real-Time Functional Assessment of In Vitro Filtration Barriers
The integrity of the barrier between blood and the selective filtrate of solutes is important for homeostasis and its disruption contributes to many...
-
Measured GFR in murine animal models: review on methods, techniques, and procedures
Chronic kidney disease (CKD) is one of the most common chronic diseases worldwide, with increasing rates of morbidity and mortality. Thus, early...
-
Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration
PurposeDrug elimination alteration has been well reported in acute lymphoblastic leukemia (ALL). Considering that transporters and glomerular...
-
Transcutaneous Measurement of Glomerular Filtration Rate in Rodents
Glomerular filtration rate (GFR) is considered the gold standard to test kidney function. However, the serial blood and/or urine sample collection...
-
A novel nomogram to predict the reliability of estimated glomerular filtration rate formulae in oncology patients
BackgroundFormulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however,...
-
Improving accuracy of estimating glomerular filtration rate using artificial neural network: model development and validation
BackgroundThe performance of previously published glomerular filtration rate (GFR) estimation equations degrades when directly used in Chinese...
-
Interleukin-6 Downregulates the Expression of Vascular Endothelial-Cadherin and Increases Permeability in Renal Glomerular Endothelial Cells via the Trans-Signaling Pathway
The pathogenesis of IgA nephropathy (IgAN) is still unknown, but reportedly, interleukin 6 (IL-6) is involved in this process. However, its role in...
-
Estimation of Renal Clearance in Hypertensive Rats According to fMRI Data
Renal clearance in Wistar rats with multifactorial cardiovasorenal model of arterial hypertension was assessed by fMRI using (EPI_Diffusion_map)...
-
Correlations Between Renal Biomarkers and the Treatment Outcomes in Diabetes: Ophthalmic Aspects
Diabetic retinopathy (DR) and diabetic nephropathy are the main microvascular complications in diabetes and often comorbid with each other. Renal...
-
Adverse kidney outcomes of CDK 4/6 inhibitors for metastatic breast cancer
Cyclin-dependent kinase (CDK) 4/6 inhibitors have significantly improved overall and progression free survival of patients with metastatic breast...
