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Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway
Gallbladder cancer (GBC) is a common malignant cancer in the biliary system, which poses a serious threat to human health. It is urgent to explore...
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Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis
Matrine is a Sophora alkaloid that exerts antitumor effects on a variety of diseases, but few studies have investigated the role of matrine in...
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Matrine Mediated Immune Protection in MS by Regulating Gut Microbiota and Production of SCFAs
There is clearly an unmet need for more effective and safer treatments for multiple sclerosis (MS). Our previous studies showed a significant...
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Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
Recent evidence suggests that misfolding, clum**, and accumulation of proteins in the brain may be common causes and pathogenic mechanism for...
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Matrine alleviates depressive-like behaviors via modulating microbiota–gut–brain axis in CUMS-induced mice
BackgroundThe realization of the “microbiota–gut–brain” axis plays a critical role in neuropsychiatric disorders, particularly depression, is...
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The effect of matrine and glycyrrhizic acid on porcine reproductive and respiratory syndrome virus in Vitro and in vivo
Porcine reproductive and respiratory syndrome (PRRS) is endemic worldwide, seriously affecting the development of the pig industry, but vaccines have...
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Five matrine-type alkaloids from Sophora tonkinensis
Five matrine-type alkaloids ( 1 ‒ 5 ) including two new compounds ( 1 and 3 ) and a new natural product ( 2 ) were isolated from the roots of Sophora...
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Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice
Pathological cardiac fibrosis is a common feature in multiple cardiovascular diseases that contributes to the occurrence of heart failure and...
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Matrine inhibits cell growth, migration, invasion and promotes autophagy in hepatocellular carcinoma by regulation of circ_0027345/miR-345-5p/HOXD3 axis
BackgroundMatrine has been reported to exert anti-tumor effects in multiple types of cancers containing hepatocellular carcinoma (HCC). However, the...
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Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy
Hypoxia-inducible Factor 1 (HIF-1) is a transcriptional activator that intervenes in versatile reactions to hypoxia. Natural drugs, widely...
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Matrine alleviates neurobehavioral alterations via modulation of JNK-mediated caspase-3 and BDNF/VEGF signaling in a mouse model of burn injury
RationaleThe c-Jun N-terminal kinase (JNK) pathway and neurotrophic factor dysregulation play a critical role in the pathogenesis of neurobehavioral...
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Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents
Using matrine (1) as the lead compound, a series of new piperazinyl matrine derivatives were designed, synthesized and evaluated for their antitumor...
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Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling
BackgroundIn the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern...
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Matrine
Matrine is an alkaloid extracted by organic solvents from the dry roots, plants, and fruits of kushen (Sophora flavescens Ait). Matrine has...
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Testis Toxicants: Lesson from Traditional Chinese Medicine (TCM)
The testis is one of the organs in the mammalian body that is sensitive to toxicants. Accumulating evidence has shown that human exposure to toxic...
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RETRACTED ARTICLE: Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways
Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora . Its anti-proliferative and pro-apoptotic effects on...
