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SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity
Cerebrospinal fluid is a clear fluid that occupies the ventricular and subarachnoid spaces within and around the brain and spinal cord. Cerebrospinal...
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Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection
The interaction between the gastric epithelium and immune cells plays key roles in H. pylori -associated pathology. Here, we demonstrate a...
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Periostin: biology and function in cancer
Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal...
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Plasma SPARC Elevation in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
Matricellular proteins have been implicated in pathologies after subarachnoid hemorrhage (SAH). To find a new therapeutic molecular target, the...
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Methods to Investigate Thrombin Cleavage of Osteopontin (OPN)
Osteopontin (OPN) is a matricellular protein containing binding sites for a variety of ligands including an RGD sequence for binding to αvβ3...
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An overview of CCN4 (WISP1) role in human diseases
CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich matricellular protein is emerging as a key player in the...
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Anti-Apoptotic Effects of AMPA Receptor Antagonist Perampanel in Early Brain Injury After Subarachnoid Hemorrhage in Mice
This study was aimed to investigate if acute neuronal apoptosis is induced by activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate)...
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Machine Learning Analysis of Matricellular Proteins and Clinical Variables for Early Prediction of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
Although delayed cerebral ischemia (DCI) is a well-known complication after subarachnoid hemorrhage (SAH), there are no reliable biomarkers to...
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Role of extra cellular proteins in gastric cancer progression and metastasis: an update
BackgroundGastric cancer (GC) is one of the most common cancers in the world with a high ratio of mortality. Regarding the late diagnosis, there is a...
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Heterozygous THBS2 pathogenic variant causes Ehlers–Danlos syndrome with prominent vascular features in humans and mice
Ehlers–Danlos syndromes (EDS) are a group of connective tissue disorders caused by mutations in collagen and collagen-interacting genes. We delineate...
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Dissecting the conformation of glycans and their interactions with proteins
The use of in silico strategies to develop the structural basis for a rational optimization of glycan-protein interactions remains a great challenge....
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Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling
BackgroundAutoimmune disorders, including Systemic Lupus Erythematosus (SLE), are associated with increased incidence of hematological malignancies....
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Periostin–TGF-β feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer
BackgroundThis study aimed to investigate the underlying mechanisms of matricellular protein periostin (POSTN) on tumour-stroma crosstalk in the...
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Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia
BackgroundReduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments...
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Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins
Collagens are the most abundant components of the extracellular matrix (ECM) and many types of soft tissues. Elastin is another major component of...
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Periostin regulation and cartilage degradation early after anterior cruciate ligament reconstruction
Objective and designThe purpose of this study was to explore pathological processes during the first 4 weeks after anterior cruciate ligament...
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Comparing the Influence of Angiotensin II and TGFβ1 on Cardiac Fibroblasts; Myofibroblast Plasticity and Resistance to Apoptosis
Heart disease with attendant cardiac fibrosis carries a major societal burden in developed countries. Recent work underscores the high diversity of...
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Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection
BackgroundThe lack of specificity and high degree of false positive and false negative rates when using mammographic screening for detecting...
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Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature
Advancements in omics methodologies have generated a wealth of high-dimensional Alzheimer’s disease (AD) datasets, creating significant opportunities...
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Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid
The detection and quantification of protein biomarkers in interstitial fluid is hampered by challenges in its sampling and analysis. Here we report...
