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Novel Presentation of Major Histocompatibility Complex Class II Deficiency with Hemophagocytic Lymphohistiocytosis
PurposeMajor histocompatibility complex (MHC) class II deficiency is one of the combined immune deficiency disorders caused by defects in the MHC...
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Recurrent Infections in an Ethiopian Boy with Autosomal Recessive Major Histocompatibility Complex Type I Deficiency: a Case Report on a Very Rare Primary Immunodeficiency Disorder and a Review of Principles in Evaluation and Management
Little is known about major histocompatibility complex type I deficiency, a rare form of primary immunodeficiency. This report describes the...
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The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and simple with few genes, most of...
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
BackgroundGastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major...
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NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis
ObjectiveThis study was designed to investigate the role of the nucleotide-binding-domain -and leucine-rich repeat -containing (NLR) family,...
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Major Histocompatibility Complex Genes
Antigen binding by B cells occurs directly with the BCR recognizing epitopes on antigens. T cell recognition of antigens cannot occur unless the...
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Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor
Pancreatic cancer is one of the deadliest neoplasms, with a dismal 5-year survival rate of only 10%. The ability of pancreatic cancer cells to evade...
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Major histocompatibility complex genes and locus organization in the Komodo dragon (Varanus komodoensis)
We performed a meta-analysis of the newly assembled Komodo dragon ( Varanus komodoensis ) genome to characterize the major histocompatibility complex...
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Antigen-Presenting Cells and the Major Histocompatibility Complex
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...
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Anti-Inflammatory Effect of Technologically Processed Antibodies to the Molecules of the Major Histocompatibility Complex in a Model of Acute Inflammation In Vivo
The anti-inflammatory effect of technologically processed antibodies (TPA) to immune targets (MHC I and MHC II) was assessed in the...
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Major histocompatibility complex (MHC) associations with diseases in ethnic groups of the Arabian Peninsula
Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of...
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DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway
Major histocompatibility complex class II (MHC II) is important for the adaptive immune response because MHC II presents processed antigens to a...
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The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation
The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. The major histocompatibility complex (MHC) class I MICA...
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IMGT/3Dstructure-DB: T-Cell Receptor TR Paratope and Peptide/Major Histocompatibility pMH Contact Sites and Epitope
T-cell receptors (TR), the antigen receptors of T cells, specifically recognize peptides presented by the major histocompatibility (MH) proteins, as...
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Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes
The association of autoimmune diseases with particular allellic products of the class-II major histocompatibility complex (MHCII) region implicates...
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HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution
The major histocompatibility complex (MHC) with its highly polymorphic HLA genes represents one of the most intensely studied genomic regions in the...
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Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice
BackgroundImmune molecules, such as cytokines, complement, and major histocompatibility complex (MHC) proteins, in the central nervous system are...
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Genotype imputation methods for whole and complex genomic regions utilizing deep learning technology
The imputation of unmeasured genotypes is essential in human genetic research, particularly in enhancing the power of genome-wide association studies...
