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Macrophage Polarization and Osteoclast Differentiation
Macrophages are a key player to regulate rheumatoid arthritis pathogenesis from onset to remission. They can alter innate functions under...
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P53 Alleviates the Progression of Periodontitis by Reducing M1-type Macrophage Differentiation
Our objective is to explore the effect of P53 on the progression of periodontitis by regulating macrophages differentiation both in vitro and in vivo. ...
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Acute and Chronic Macrophage Differentiation Modulates TREM2 in a Personalized Alzheimer’s Patient-Derived Assay
Neuroinflammation plays a pivotal role in the pathogenesis of Alzheimer`s disease (AD). Brain macrophage populations differentially modulate the...
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CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation through NF-κB signaling pathway in ankylosing spondylitis in vitro
BackgroundAnkylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton...
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MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM...
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Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype
BackgroundMacrophages (M φ ) can exist along a spectrum of phenotypes that include pro-inflammatory (M1) or anti-inflammatory (M2) immune cells. M φ ...
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ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment
In inflamed tissues, monocytes differentiate into macrophages (mo-Macs) or dendritic cells (mo-DCs). In chronic nonresolving inflammation, mo-DCs are...
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Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance
BackgroundGemcitabine resistance (GR) is a significant clinical challenge in pancreatic adenocarcinoma (PAAD) treatment. Macrophages in the tumor...
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Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions
We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. All...
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Parishin A-loaded mesoporous silica nanoparticles modulate macrophage polarization to attenuate tendinopathy
Macrophages are involved mainly in the balance between inflammation and tenogenesis during the healing process of tendinopathy. However, etiological...
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TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα
BackgroundHuman aging is characterized by a state of chronic inflammation, termed inflammaging, for which the causes are incompletely understood. It...
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Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment
BackgroundChronic inflammation and fibrosis are characteristics of silicosis, and the inflammatory mediators involved in silicosis have not been...
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Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation
Heme metabolism is a key regulator of inflammatory responses. Cobalt protoporphyrin IX (CoPP) is a heme analog and mimic that potently activates the...
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Integrated transcriptional analysis reveals macrophage heterogeneity and macrophage-tumor cell interactions in the progression of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease harboring significant microenvironment heterogeneity, especially for the...
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Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasets
BackgroundCardiac fibrosis after myocardial infarction (MI) has been considered an important part of cardiac pathological remodeling. Immune cells,...
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Tricarboxylic acid cycle metabolites: new players in macrophage
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid...
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Serine metabolism in macrophage polarization
ObjectiveEmerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of serine for their...
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The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor...
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Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses
IntroductionMacrophages (Mφs) are functionally dynamic immune cells that bridge innate and adaptive immune responses; however, the underlying...
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DNA methyltransferase 1 deficiency improves macrophage motility and wound healing by ameliorating cholesterol accumulation
Healing of the cutaneous wound requires macrophage recruitment at the sites of injury, where chemotactic migration of macrophages toward the wound is...
