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MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination
Chronic cerebral hypoperfusion is one of the pathophysiological mechanisms contributing to cognitive decline by causing white matter injury....
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MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
Brain accumulation of amyloid-beta (Aβ) is a crucial feature in Alzheimer´s disease (AD) and cerebral amyloid angiopathy (CAA), although the...
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Propofol suppresses microglial phagocytosis through the downregulation of MFG-E8
BackgroundMicroglia are highly motile phagocytic cells in the healthy brain with surveillance and clearance functions. Although microglia have been...
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MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells
BackgroundAmong older adults, arterial aging is the major factor contributing to increased risk for cardiovascular disease–related morbidity and...
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Immunological and Clinicopathological Significance of MFG-E8 Expression in Patients with Oral Squamous Cell Carcinoma
Milk fat globule-epidermal growth factor 8 (MFG-E8) is a glycoprotein secreted by the activated macrophages and acts as a bridge between apoptotic...
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Preventing SARS-CoV-2 Infection Using Anti-spike Nanobody-IFN-β Conjugated Exosomes
PurposeTo inhibit the transmission of SARS-CoV-2, we developed engineered exosomes that were conjugated with anti-spike nanobodies and type I...
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Recombinant human milk fat globule-EGF factor VIII (rhMFG-E8) as a therapy for sepsis after acute exposure to alcohol
BackgroundAlcohol intake predisposes to infections and sepsis. Alcohol and sepsis inhibit the expression of milk fat globule epidermal growth...
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Secreted Glycoproteins That Regulate Synaptic Function: the Dispatchers in the Central Nervous System
Glycoproteins are proteins that contain oligosaccharide chains. As widely distributed functional proteins in the body, glycoproteins are essential...
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The Retinal Pigment Epithelium: Cells That Know the Beat!
The retinal pigment epithelium (RPE) ensures different functions crucial for photoreceptor survival, and thus for vision, such as photoreceptor outer...
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Unique asymmetric distribution of phosphatidylserine and phosphatidylethanolamine in Toxoplasma gondii revealed by nanoscale analysis
Toxoplasma gondii is a highly prevalent obligate apicomplexan parasite that is important in clinical and veterinary medicine. It is known that...
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After cell death: the molecular machinery of efferocytosis
Cells constituting a multicellular organism die in a variety of ways throughout life, and most of them die via apoptosis under normal conditions. The...
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Macrophages and cancer stem cells: a malevolent alliance
Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are...
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Modification of Extracellular Vesicle Surfaces: An Approach for Targeted Drug Delivery
AbstractExtracellular vesicles (EVs) are a promising drug delivery vehicle candidate because of their natural origin and intrinsic function of...
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Generation of Cancer Stem Cells by Co-Culture Methods
Cancer stem cells (CSCs) exhibit intricate regulatory dynamics within the tumor microenvironment, involving interactions with various components like...
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Extracellular Vesicle Engineering for Clinical Therapy
Engineering the extracellular vesicle (EV) membrane may be an interesting approach for endowing EVs with additional biological properties. In this...
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TGF-β1 signalling in Alzheimer’s pathology and cytoskeletal reorganization: a specialized Tau perspective
Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its detachment from microtubules and formation of insoluble...
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A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression
Cancer progression largely depends on tumor blood vessels as well on immune cell infiltration. In various tumors, vascular cells, namely endothelial...
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Perspectives and Challenges on the Potential Use of Exosomes in Bioartificial Pancreas Engineering
Exosomes are enclosed within a single outer membrane and exemplify a specific subtype of secreted vesicles. Exosomes transfer signalling molecules,...
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Efferocytosis and the Story of “Find Me,” “Eat Me,” and “Don’t Eat Me” Signaling in the Tumor Microenvironment
The process of efferocytosis involves removal of dying or dead cells by phagocytosis. Another term “efferosome” is used which means a fluid-filled...