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1. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

   Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known...

   Raquel García-Vílchez, Ana M. Añazco-Guenkova, ... Sandra Blanco in Molecular Cancer

   Article Open access 29 July 2023
   

2. P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC

   Background

   N7-methylguanosine (m7G) modification is, a more common epigenetic modification in addition to m6A modification, mainly found in mRNA...

   Mingpeng Zhang, Duo Kan, ... Zhiqun Shang in Journal of Experimental & Clinical Cancer Research

   Article Open access 21 August 2023
   

3. M7G methylated core genes (METTL1 and WDR4) and associated RNA risk signatures are associated with prognosis and immune escape in HCC

   N7 methylguanosine (m7G) has a crucial role the development of hepatocellular carcinoma (HCC). This study aimed to investigate the impact of the m7G...

   Rui Li, **ncheng Liu, ... **n Wang in BMC Medical Genomics

   Article Open access 01 August 2023
   

4. METTL1-mediated tRNA m⁷G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade

   Background

   RNA modifications of transfer RNAs (tRNAs) are critical for tRNA function. Growing evidence has revealed that tRNA modifications are...

   Dan Du, Mingxia Zhou, ... **g He in Journal of Experimental & Clinical Cancer Research

   Article Open access 31 May 2024
   

5. METTL1 promotes neuroblastoma development through m⁷G tRNA modification and selective oncogenic gene translation

   Background

   Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high...

   Ying Huang, Jieyi Ma, ... Libin Huang in Biomarker Research

   Article Open access 07 September 2022
   

6. Prognostic role of METTL1 in glioma

   Background

   Current treatment options for glioma are limited, and the prognosis of patients with glioma is poor as the available drugs show low...

   Lun Li, Yi Yang, ... Guangyu Li in Cancer Cell International

   Article Open access 27 November 2021
   

7. COVPRIG robustly predicts the overall survival of IDH wild-type glioblastoma and highlights METTL1⁺ neural-progenitor-like tumor cell in driving unfavorable outcome

   Background

   Accurately predicting the outcome of isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) remains hitherto challenging. This study...

   Hang Ji, Fang Wang, ... Yi Liu in Journal of Translational Medicine

   Article Open access 08 August 2023
   

8. METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN

   Abstract

   RNA methylation is emerging as an important regulator of gene expression. Dysregulation of methyltransferase that is essential for RNA...

   Qiu-Hong Tian, Mei-Fang Zhang, ... Jian-** **ong in Journal of Molecular Medicine

   Article 28 August 2019
   

9. RNA modification: mechanisms and therapeutic targets

   RNA modifications are dynamic and reversible chemical modifications on substrate RNA that are regulated by specific modifying enzymes. They play...

   Lei Qiu, Qian **g, ... Junhong Han in Molecular Biomedicine

   Article Open access 24 August 2023
   

10. RNA modifications in cancer

    Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of...

    Qiling Tang, Lvyuan Li, ... Wei **ong in British Journal of Cancer

    Article 24 April 2023
    

11. Emerging role of RNA modification and long noncoding RNA interaction in cancer

    RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression...

    Liqiong Yang, Lu Tang, ... **g Shen in Cancer Gene Therapy

    Article Open access 14 February 2024
    

12. The role of RNA methylation in tumor immunity and its potential in immunotherapy

    RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control...

    Yan Li, Haoer **, ... Luqing Zhao in Molecular Cancer

    Article Open access 20 June 2024
    

13. Transfer RNAs as dynamic and critical regulators of cancer progression

    Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode the genetic code into proteins. Recent work has uncovered...

    Alexandra M. Pinzaru, Sohail F. Tavazoie in Nature Reviews Cancer

    Article 09 October 2023
    

14. Advances in radiotherapy and immunity in hepatocellular carcinoma

    Primary liver cancer is one of the most common malignant tumours worldwide; it caused approximately 830,000 deaths in 2020. Hepatocellular carcinoma...

    Yuhan Yang, Liting **ong, ... Chunxiao Li in Journal of Translational Medicine

    Article Open access 04 August 2023
    

15. An innovative model based on N7-methylguanosine-related lncRNAs for forecasting prognosis and tumor immune landscape in bladder cancer

    Background

    As a novel type of the prevalent post-transcriptional modifications, N7-methylguanosine (m7G) modification is essential in the...

    Lei Ren, Xu Yang, ... **aopeng Mao in Cancer Cell International

    Article Open access 08 May 2023
    

16. M7G-Related lncRNAs predict prognosis and regulate the immune microenvironment in lung squamous cell carcinoma

    Background

    N7-Methylguanosine (m7G) and long non-coding RNAs (lncRNAs) have been widely studied in cancer and have been found to be useful for...

    Junfan Pan, Zhidong Huang, ... Jiancheng Li in BMC Cancer

    Article Open access 04 November 2022
    

17. Underexplored reciprocity between genome-wide methylation status and long non-coding RNA expression reflected in breast cancer research: potential impacts for the disease management in the framework of 3P medicine

    Breast cancer (BC) is the most common female malignancy reaching a pandemic scale worldwide. A comprehensive interplay between genetic alterations...

    Andrea Kapinova, Alena Mazurakova, ... Peter Kubatka in EPMA Journal

    Article Open access 22 May 2023
    

18. Insights into the regulatory role of RNA methylation modifications in glioma

    Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial...

    Shengrong Long, Yu Yan, ... **ang Li in Journal of Translational Medicine

    Article Open access 14 November 2023
    

19. tRNA dysregulation and disease

    tRNAs are key adaptor molecules that decipher the genetic code during translation of mRNAs in protein synthesis. In contrast to the traditional view...

    Esteban A. Orellana, Elisabeth Siegal, Richard I. Gregory in Nature Reviews Genetics

    Article 09 June 2022
    

20. RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma

    Multiple transcript isoforms of genes can be formed by processing and modifying the 5′ and 3′ ends of RNA. Herein, the aim of this study is to...

    **nhui Li, Shan Liu, ... Chaobei Zhu in Genes & Immunity

    Article 12 March 2024