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Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells
MEN1 mutation causes pancreatic neuroendocrine neoplasia and benign malignancies of the parathyroid, the adrenal cortex and pituitary gland. The...
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MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin
BackgroundRecent studies highlighted the increased frequency of AR-low or -negative prostate cancers (PCas) and the importance of AR-independent...
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A novel mutation of the MEN1 gene in a patient with multiple endocrine neoplasia type 1 and recurrent fibromyxoid sarcoma – a case report
BackgroundMultiple endocrine neoplasia type 1 (MEN1) syndrome is usually accompanied by endocrine tumors, but non-endocrine tumors can occur as well....
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Multiple endocrine neoplasia type 1: a new germline “homozygous” variant (c.201delC) caused by detection errors
BackgroundMultiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome caused by germline variants in the MEN1 gene located on...
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Comprehensive genomic and transcriptomic characterization of high-grade gastro-entero-pancreatic neoplasms
BackgroundHigh-grade gastro-entero-pancreatic neoplasms (HG GEP-NENs) can be stratified according to their morphology and Ki-67 values into three...
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Molecular Mechanisms of Carcinogenesis Associated with MEN1 Gene Mutation
AbstractDespite recent advances in genomics and the discovery of numerous genes involved in carcinogenesis, the mechanisms of malignant...
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Loss of tumor suppressor menin expression in high grade cholangiocarcinomas
BackgroundMEN1 , which codes for the protein menin, is a tumor suppressor in neuroendocrine tissue. In cholangiocarcinoma (CCA) cell lines the...
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Massive parallel sequencing in individuals with multiple primary tumours reveals the benefit of re-analysis
Multiple primary cancers, defined as three or more primary tumours, are rare, and there are few genetic studies concerning them. There is a need for...
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Management of patients with presumed germline pathogenic variant from tumor-only genomic sequencing: A retrospective analysis at a single facility
Cancer treatment is increasingly evolving toward personalized medicine, which sequences numerous cancer-related genes and identifies therapeutic...
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Preimplantation genetic testing in patients with genetic susceptibility to cancer
Data on preimplantation genetic testing (PGT-M) in patients with genetic susceptibility to cancer are scarce in the literature, while there is, in...
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Cancer predisposition genes in Japanese children with rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is one of the most common soft tissue sarcomas in children. Germline mutations in cancer-predisposition genes have been...
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High Homocysteine-Thiolactone Leads to Reduced MENIN Protein Expression and an Impaired DNA Damage Response: Implications for Neural Tube Defects
DNA damage is associated with hyperhomocysteinemia (HHcy) and neural tube defects (NTDs). Additionally, HHcy is a risk factor for NTDs. Therefore,...
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Itaconate inhibits corticosterone-induced necroptosis and neuroinflammation via up-regulating menin in HT22 cells
Corticosterone (CORT) damages hippocampal neurons as well as induces neuroinflammation. The tricarboxylic acid cycle metabolite itaconate has an...
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An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway
Tumor organoids recapitulate pathological properties and would serve as an excellent ex vivo model for drug discovery. Here, we performed an unbiased...
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Genetic evaluation of patients and families with concern for hereditary endocrine tumor syndromes
Hereditary endocrine tumor syndromes are rare conditions with overlap** features. It is imperative that healthcare providers differentiate between...
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Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes
Several medical conditions that interest both the brain and the spinal cordSpinal cord have been described throughout the history of medicine....
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Combinatorial targeting of menin and the histone methyltransferase DOT1L as a novel therapeutic strategy for treatment of chemotherapy-resistant ovarian cancer
BackgroundOvarian cancer (OC) is characterized by a low response rate and high frequency of resistance development to currently available treatments....
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Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
Monotherapy with Menin inhibitor (MI), e.g., SNDX-5613, induces clinical remissions in patients with relapsed/refractory AML harboring MLL1-r or...
