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On the onset and dispersal of a major MDR TB clone among HIV-negative patients, Tunisia
BackgroundTo carry out a whole genome sequencing (WGS)-based investigation on the emergence and spread of the largest multidrug-resistant...
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A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects
FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance development. Thus, FAK inhibition has emerged as an effective...
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Global burden of MDR-TB and XDR-TB attributable to high fasting plasma glucose from 1990 to 2019: a retrospective analysis based on the global burden of disease study 2019
PurposeHigh fasting plasma glucose (HFPG) has been identified as a risk factor for drug-resistant tuberculosis incidence and mortality. However, the...
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Risk factors and outcome associated with the acquisition of MDR linezolid-resistant Enterococcus faecium: a report from tertiary care centre
ObjectiveThe aim of the study was to determine the resistance profile of linezolid-resistant Enterococcus faecium (LREfm) and to investigate risk...
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TM2, a novel semi-synthetic taxoid, exerts anti-MDR activity in NSCLC by inhibiting P-gp function and stabilizing microtubule polymerization
Taxane agents are of particular interest in non-small cell lung carcinomas (NSCLC) treatment, while multidrug resistance (MDR) mediated by...
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Biosynthesis and characterisations of silver nanoparticles with filamentous cyanobacterium Lyngbya sp. with in vitro antibacterial properties against MDR pathogenic bacteria
This study describes phycocompounds of the non-N 2 -fixing filamentous cyanobacterium Lyngbya sp., which has potential bio-reducing and stabilizing...
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Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the develo** human blood–brain barrier
BackgroundThe multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by ABCB1 ) and breast cancer resistance protein (BCRP/ ABCG2 )...
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Phages and Their Derived Proteins As Promising Alternatives to Mitigate MDR Salmonellae
Antibiotics are considered as “wonder drugs” to combat microbial infections for decades ever since their discovery. Unfortunately, the arrival of...
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Phages and Their Derived Proteins as Promising Alternatives to Mitigate MDR Salmonellae
Antibiotics are considered as “wonder drugs” to combat microbial infections for decades ever since their discovery. Unfortunately, the arrival of...
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The Effect of the ABCB1(MDR-1) C3435T Polymorphism in Turkish Patients with Aspirin Resistance in Acute Ischemic Stroke
Recurrence of thrombotic events during aspirin therapy is known as aspirin resistance (AR). This study aimed to investigate the rate of AR, the...
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Therapeutic Drug Monitoring and Prolonged Infusions of Ceftolozane/Tazobactam for MDR/XDR Pseudomonas aeruginosa Infections: An Observational Study
Background and ObjectiveProlonged infusion of ceftolozane/tazobactam (C/T) is a strategy used to increase achievement of...
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Role of Gold Nanoparticles Against Multidrug Resistance (MDR) Bacteria: An Emerging Therapeutic Revolution
Multidrug resistance (MDR) due to extensive futile use of antibiotics exhibits as an emerging menace to human health toward diagnosis and treatment....
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CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells
BackgroundMultidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy...
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High frequency of multidrug-resistant (MDR) Klebsiella pneumoniae harboring several β-lactamase and integron genes collected from several hospitals in the north of Iran
BackgroundKlebsiella pneumoniae is one of the leading causes of hospital outbreaks worldwide. Also, antibiotic-resistant K. pneumoniae is...
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Optimizing Bedaquiline for cardiotoxicity by structure based virtual screening, DFT analysis and molecular dynamic simulation studies to identify selective MDR-TB inhibitors
Since the last 4 decades, Bedaquiline has been the first drug discovered as a new kind of anti-tubercular agent and received FDA approval in December...
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Dissemination of mcr-1 and β-lactamase genes among Pseudomonas aeruginosa: molecular characterization of MDR strains in broiler chicks and dead-in-shell chicks infections
ObjectivesPseudomonas aeruginosa ( P. aeruginosa) is one of the most serious pathogens implicated in antimicrobial resistance, and it has been...
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β-lactamase-mediated resistance in MDR-Pseudomonas aeruginosa from Qatar
BackgroundThe distribution of β-lactam resistance genes in P. aeruginosa is often closely related to the distribution of certain high-risk...
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MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era
BackgroundMultidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing...
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Tweaking EMT and MDR dynamics to constrain triple-negative breast cancer invasiveness by EGFR and Wnt/β-catenin signaling regulation
PurposeDue to a lack of effective targeted therapies, patients with metastatic triple-negative breast cancer (TNBC) have poor clinical outcomes....
