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Impacts of liver macrophages, gut microbiota, and bile acid metabolism on the differences in iHFC diet-induced MASH progression between TSNO and TSOD mice
BackgroundTsumura-Suzuki non-obese (TSNO) mice exhibit a severe form of metabolic dysfunction-associated steatohepatitis (MASH) with advanced liver...
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Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis
BackgroundMetabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models...
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FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of...
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Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells
BackgroundDysregulation of immune surveillance is tightly linked to the development of metabolic dysfunction-associated steatohepatitis (MASH)-driven...
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ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis
BackgroundNon-alcoholic Fatty Liver Disease (NAFLD), now better known as Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD) and its...
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Heterocyclic Amines Disrupt Lipid Homeostasis in Cryopreserved Human Hepatocytes
Metabolic dysfunction associated-steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) is the liver manifestation...
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The potential role of omentin-1 in obesity-related metabolic dysfunction-associated steatotic liver disease: evidence from translational studies
BackgroundObesity, characterized by visceral adipose tissue (VAT) expansion, is closely associated with metabolic dysfunction-associated steatotic...
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Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic...
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Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial
Retatrutide is a novel triple agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 and glucagon receptors. A 48-week...
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Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment
Liver disease is a significant health burden globally and accounts for 4% of total deaths annually. Alcoholic liver disease (ALD) and...
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Antimicrobial resistance survey and whole-genome analysis of nosocomial P. Aeruginosa isolated from eastern Province of China in 2016–2021
BackgroundPseudomonas aeruginosa is a major Gram-negative pathogen that can exacerbate lung infections in the patients with cystic fibrosis, which...
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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to...
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High-resolution strain-level microbiome composition analysis from short reads
BackgroundBacterial strains under the same species can exhibit different biological properties, making strain-level composition analysis an important...
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Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that can progress to end-stage...
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Intranasal Insulin Enhances Intracerebroventricular Streptozotocin–Induced Decrease in Olfactory Discriminative Learning via Upregulation of Subventricular Zone–Olfactory Bulb Neurogenesis in the Rat Model
Olfactory perception and learning play a vital role in the animal’s entire life for habituation and survival. Insulin and insulin receptor signaling...
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Abnormal protein SUMOylation in liver disease: novel target for therapy
SUMOylation is an important protein post-translational modification (PTM) process, in which the small ubiquitin-like modifier (SUMO) protein...
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Clinical and genomic features of Mycobacterium avium complex: a multi-national European study
BackgroundThe Mycobacterium avium complex (MAC) comprises the most frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently...
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Characterization of metagenome-assembled genomes from the International Space Station
BackgroundSeveral investigations on the microbial diversity and functional properties of the International Space Station (ISS) environment were...
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Plasma ALS and Gal-3BP differentiate early from advanced liver fibrosis in MASLD patients
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect 30% of the world’s population, and its prevalence...
