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Poor clinical guideline adherence and inappropriate testing for incident lower urinary tract symptoms associated with benign prostatic hyperplasia
BackgroundThe American Urological Association makes recommendations for evaluation and testing for lower urinary tract symptoms associated with...
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Delineating three-dimensional behavior of uveal melanoma cells under anchorage independent or dependent conditions
BackgroundAlthough rare, uveal melanoma (UM) is a life-threatening malignancy. Understanding its biology is necessary to improve disease outcome....
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Real-World Evidence of the Top 100 Prescribed Drugs in the USA and Their Potential for Drug Interactions with Nirmatrelvir; Ritonavir
Nirmatrelvir (coadministered with ritonavir as PAXLOVID TM ) reduces the risk of COVID-19-related hospitalizations and all-cause death in individuals...
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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4 + T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8 + cytotoxic T lymphocyte (CTL) anticancer responses, as...
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Artificial Intelligence in Intensive Care Medicine: Toward a ChatGPT/GPT-4 Way?
Although intensive care medicine (ICM) is a relatively young discipline, it has rapidly developed into a full-fledged and highly specialized...
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Usefulness of monitoring circulating tumor cells as a therapeutic biomarker in melanoma with BRAF mutation
BackgroundWhile molecularly targeted therapies and immune checkpoint inhibitors have improved the prognosis of advanced melanoma, biomarkers are...
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Molecular mimicry and cancer vaccine development
BackgroundThe development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which...
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Influence of the trajectory of the urine output for 24 h on the occurrence of AKI in patients with sepsis in intensive care unit
BackgroundSepsis-associated acute kidney injury (S-AKI) is a common and life-threatening complication in hospitalized and critically ill patients....
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Euterpe oleracea Mart. (Açaí) attenuates experimental colitis in rats: involvement of TLR4/COX-2/NF-ĸB
Euterpe oleracea Mart., commonly known as açaí, has been demonstrated to exhibit significantly antioxidant and inflammatory activities in...
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TIM-3 regulates the proliferation by BDNF-mediated PI3K/AKT axis in the process of endometriosis
BackgroundT cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) initially discovered on the surface of Th1 cells, negatively regulates...
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Traditional medicinal plants used in the treatment of viral diseases
Nowadays, theoretical chemistry has experienced a great advance in the search for drugs for the treatment of various human and animal pathologies....
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Extracellular Vesicles in Cancer Immunotherapy
Extracellular vesicles (EVs) are nanoscale vesicles that contain a repertoire of molecules representing the cell of origin. Cancer cell-derived EVs... -
Açaí (Euterpe oleracea Mart.) as a Potential Anti-neuroinflammatory Agent: NLRP3 Priming and Activating Signal Pathway Modulation
Neurological disorders have been demonstrated to be associated with mitochondrial dysfunction. This impairment may lead to oxidative stress and...
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Identification of BACH1-IT2-miR-4786-Siglec-15 immune suppressive axis in bladder cancer
The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive...
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Development of Immune Cell Therapy Using T Cells Generated from Pluripotent Stem Cells
In the field of cancer immunotherapy, the effectiveness of a method in which patient-derived T cells are genetically modified ex vivo and... -
MART-1
MART-1 (melanoma antigen recognized by T cells) is also known as Melan-A. It has gained wide acceptance as an immunohistochemical marker to diagnose... -
Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived...
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Animal Models for Cancer Immunology
Purpose of ReviewThis review discusses the characteristics of different in vivo experimental immunologic models for the development of...
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Melanocytes in regenerative medicine applications and disease modeling
Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the...
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T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects, amplifies and coordinates cellular immune responses to...