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MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of...
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Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas
BackgroundRecent evidences have shown that circular RNAs (circRNAs) are frequently dysregulated and play paramount roles in various cancers. circRNAs...
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MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer
BackgroundCervical cancer is one of the most common cancers among females worldwide and advanced patients have extremely poor prognosis. However,...
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MiR-7 deficiency promotes Th1 polarization of CD4+T cells and enhances the antitumor effect in adoptive cell therapy for lung cancer
Adoptive-cell-therapy (ACT) is important therapeutic approach against cancer. We previously showed that miR-7 deficiency endowed CD4 + T cells with...
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Exosome-mediated secretion of miR-127-3p regulated by RAB27A accelerates metastasis in renal cell carcinoma
BackgroundThe exosome-mediated extracellular secretion of miRNAs occurs in many cancers, and RAB27A is a potent regulator of exosome secretion. For...
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CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway
BackgroundMultiple myeloma (MM) accounts for 10% of all hematological malignancies. Dysregulation of microRNAs (miRNAs) or long non-coding RNAs...
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Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery
Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown....
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Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput...
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ADAMTS9-AS1 Long Non‑coding RNA Sponges miR‑128 and miR-150 to Regulate Ras/MAPK Signaling Pathway in Glioma
Glioma is a malignancy of the central nervous system with a poor prognosis. Therefore, the elaboration of its molecular features creates therapeutic...
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Identification of PIK3CA multigene mutation patterns associated with superior prognosis in stomach cancer
BackgroundPIK3CA is the second most frequently mutated gene in cancers and is extensively studied for its role in promoting cancer cell resistance...
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Neuroprotective effect of green and roasted coffee bean extracts on cerebral ischemia-induced injury in rats
Stroke is a lethal event with a high incidence in Egypt. Quick early intervention can be lifesaving. Transient global ischemia (TGI), a type of...
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Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
BackgroundGaining insight into molecular signalling pathways of socioeconomically important parasitic nematodes has implications for understanding...
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Circular RNA hsa_circ_0002483 promotes growth and invasion of lung adenocarcinoma by sponging miR-125a-3p
BackgroundIncreasing evidence indicates that the aberrant expression of circular RNAs (circRNAs) is involved in the pathogenesis and progression of...
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Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease–gene association
The application of next-generation sequencing (NGS) to clinical practice is still hampered by the ability to interpret the clinical relevance of...
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Identification and validation of signal recognition particle 14 as a prognostic biomarker predicting overall survival in patients with acute myeloid leukemia
BackgroundThis study aimed to determine and verify the prognostic value and potential functional mechanism of signal recognition particle 14 (SRP14)...
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Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus
BackgroundDysregulation of brain fluid homeostasis associates with brain pathologies in which fluid accumulation leads to elevated intracranial...
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Circular RNAs: typical biomarkers for bone-related diseases
Bone is a connective tissue that has important functions in the human body. Cells and the extracellular matrix (ECM) are key components of bone and...
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Clinical application of targeted tumour sequencing tests for detecting ERBB2 amplification and optimizing anti-HER2 therapy in gastric cancer
BackgroundEvaluation of human epidermal growth factor receptor 2 (HER2) overexpression caused by erb-b2 receptor tyrosine kinase 2 ( ERBB2 )...
