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Integrated analysis of tumor-associated macrophages and M2 macrophages in CRC: unraveling molecular heterogeneity and develo** a novel risk signature
BackgroundEmerging investigations have increasingly highlighted the critical role of tumor-associated macrophages (TAMs) and M2 macrophages in cancer...
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Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages
BackgroundMacrophages play a crucial role in the development of cardiac fibrosis (CF). Although our previous studies have shown that glycogen...
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Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages
Immunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer therapy. Phosphoglycerate...
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Photobiomodulation Increases M2-Type Polarization of Macrophages by Inhibiting Versican Production After Spinal Cord Injury
Spinal cord injury (SCI) is a catastrophic accidence with little effective treatment, and inflammation played an important role in that. Previous...
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Stefin B alleviates the gouty arthritis in mice by inducing the M2 polarization of macrophages
The present study aims to explore the therapeutic effect of Stefin B on gouty arthritis (GA) and the polarization of macrophages in mice. Stefin...
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APOC1 is a prognostic biomarker associated with M2 macrophages in ovarian cancer
BackgroundRecent studies have demonstrated that APOC1 is associated with cancer progression, exerting cancer-promoting and immune...
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Exosomal MiR-381 from M2-polarized macrophages attenuates urethral fibroblasts activation through YAP/GLS1-regulated glutaminolysis
Objective and designPost-traumatic urethral stricture is a clinical challenge for both patients and clinicians. Targeting glutamine metabolism to...
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LncRNA CRNDE promotes hepatoma cell proliferation by regulating the metabolic reprogramming of M2 macrophages via ERK pathway
BackgroundLncRNA colorectal neoplasia differentially expressed (CRNDE) was found to be an important regulator in many cancers. This project focuses...
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Blue light irradiation inhibits the M2 polarization of the cancer-associated macrophages in colon cancer
Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in...
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Cytohesin-4 Upregulation in Glioma-Associated M2 Macrophages Is Correlated with Pyroptosis and Poor Prognosis
Cytohesin-4 (CYTH4) is a member of the PSCD family. Members of this family appear to mediate the regulation of protein sorting and membrane...
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METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis
BackgroundThe regulatory role of N6-methyladenosine (m6A) modification in the onset and progression of cancer has garnered increasing attention in...
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Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3
PurposeOur study aimed to investigate the function of Cavin-1 and SOCS3 in macrophages/microglia M2 polarization and further explored the relevant...
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Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype
BackgroundMacrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury and repair. These...
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Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy
BackgroundTumor-associated macrophages (TAMs) play a pivotal role in resha** the tumor microenvironment following radiotherapy. The mechanisms...
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Human umbilical cord blood mononuclear cells ameliorate ischemic brain injury via promoting microglia/macrophages M2 polarization in MCAO Rats
Cerebral infarction is one of the most prevalent cerebrovascular disorders. Microglia and infiltrating macrophages play a key role in regulating the...
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CircHSPB6 Promotes Tumor-Associated Macrophages M2 Polarization and Infiltration to Accelerate Cell Malignant Properties in Lung Adenocarcinoma by CCL2
Circular RNAs (circRNAs) are reported to be involved in the tumorigenesis of lung adenocarcinoma (LUAD). Here, this study focused on studying the...
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Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer
BackgroundTumor-associated macrophages are considered to be a major contributor affecting the development of tumors. Recently, numerous studies have...
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Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells
Macrophages are widely distributed immune cells that contribute to tissue homeostasis. Human THP-1 cells have been widely used in various...
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LINC00543 promotes colorectal cancer metastasis by driving EMT and inducing the M2 polarization of tumor associated macrophages
BackgroundThe interaction between the tumor-microenvironment (TME) and the cancer cells has emerged as a key player in colorectal cancer (CRC)...
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Exosomal PGE2 from M2 macrophages inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis
BackgroundExcess polymorphonuclear neutrophil (PMN) recruitment or excessive neutrophil extracellular trap (NET) formation can lead to the...
