Search
Search Results
-
The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties
Alchemilla kiwuensis Engl. (Rosaceae) (A. kiwuensis) is an herbaceous plant traditionally used by Cameroonians to treat epilepsy and other central...
-
Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals
The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals....
-
Effects of Autoclaving and Freeze-Drying on Physicochemical Properties of Plectranthus esculentus Starch Derivatives
The goal of this research was to assess the effects of autoclaving followed by freeze-drying on acetylated xerogel (AXS) and carboxymethylated (CMS)...
-
Specific Studies for Formulation Development
Formulation development HMR456 modified release formulations The bioavailability of a drug depends on the properties of the drug product,...
-
Neurodevelopmental Disorders in Children: Neuroplasticity and the Possibilities of Nootropic Pharmacotherapy
Abstract —Neurodevelopmental Disorders (NDDs) are characterized by disturbances in the formation of cognitive functions, communication skills,...
-
Opportunities in an Evolving Pharmaceutical Development Landscape: Product Differentiation of Biopharmaceutical Drug Products
The current perspective reviews the biopharmaceutical market until end of 2020 and highlights the transforming biopharmaceutical landscape during the...
-
Desmopressin therapy in children and adults: pharmacological considerations and clinical implications
PurposeThis review aims to provide prescribing clinicians a deeper appreciation of desmopressin’s clinical indications and formulation types, to...
-
Medication-Assisted Treatment (MAT) 1: Opioid Substitution Therapy
This chapter is the first of two parts describing the advantages, standards, and goals of medication-assisted treatment (MAT) for opioid use...
-
Claiming desmopressin therapeutic equivalence in children requires pediatric data: a population PKPD analysis
PurposeFor a new formulation of a drug, only pharmacokinetic bioequivalence with the original formulation has to be demonstrated in healthy, young...
-
Specific Studies for Formulation Development
Formulation development HMR456 modified release formulations The bioavailability of a drug depends on the properties of the drug product,...
-
Quercetin-Loaded Mesoporous Silica Nanoparticle–Based Lyophilized Tablets for Enhanced Physicochemical Features and Dissolution Rate: Formulation, Optimization, and In Vitro Evaluation
Mesoporous silica nanoparticles (MSNPs) have been proposed as a potential approach for stabilizing the amorphous state of poorly water-soluble...
-
Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy,...
-
Anticonvulsant effect and acute toxicity study of the aqueous lyophilized extract of four medicinal plants of Cameroon: Malvaviscus arboreus, Alchemilla kiwuensis and mixture of Drymaria cordata and Markhamia lutea
Epilepsy is a chronic disease of the central nervous system that affects nearly 1% of the world's population and remains a major public health...
-
Case Study in the Design of a Surrogate Solution for Use in Biopharmaceutical Drug Product Process Development
The use of an aqueous-based surrogate solution in at-scale process development for biopharmaceutical drug products enables significant reduction in...
-
Lyophilization of Synthetic Gene Carriers
Lyophilization, also known as freeze drying, is a widely used method for stabilization, improvement of long-term storage stability, and...
-
Pharmacogenomic phase transition from personalized medicine to patient-centric customized delivery
Personalized medicine has been a booming area in clinical research for the past decade, in which the detailed information about the patient genotype...
-
Solubility, Opalescence, and Particulate Matter
“AppearanceAppearance ” is an analytical test often found in specifications of protein drugDrug/device combination products products. However,...
-
Effect of heat processing on the chemical constituents and NO-suppressing activity of Bletilla Tuber
Bletilla Tuber (dried tuber of Bletilla striata ) is used as an astringent hemostatic medicine for the treatment of ulcers, bleeding, and burns in...
-
Chromosomal Aberration Test in Human Lymphocytes
Human peripheral lymphocytes (HPL) are non-cycling primary cells (G0 cells). They are easily collectable by venipuncture. In the presence of suitable...
-
Consumption of a Leuconostoc holzapfelii-enriched synbiotic beverage alters the composition of the microbiota and microbial extracellular vesicles
Synbiotics, the combination of probiotics and prebiotics, are known to confer health benefits via intestinal microbiota modulation. However,...
