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Mendelian Causes of Autoimmunity: the Lupus Phenotype
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by its large heterogeneity in terms of clinical presentation...
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Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)
BackgroundThe pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic lupus erythematosus (SLE). However,...
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Lupus progression deteriorates oogenesis quality in MRL/lpr mice
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous...
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Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus
Rare genetic variants in toll-like receptor 7 (TLR7) are known to cause lupus in humans and mice. UNC93B1 is a transmembrane protein that regulates...
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Immunogenetics of Lupus Erythematosus
Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations ranging from localized lesions in cutaneous lupusCutaneous...
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Lupus nephritis or not? A simple and clinically friendly machine learning pipeline to help diagnosis of lupus nephritis
ObjectiveDiagnosis of lupus nephritis (LN) is a complex process, which usually requires renal biopsy. We aim to establish a machine learning pipeline...
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SHP2: its association and roles in systemic lupus erythematosus
ObjectiveSystemic lupus erythematosus (SLE) is an autoimmune inflammatory disease. Src homology 2 domain containing protein tyrosine phosphatase...
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IL-38, a potential therapeutic agent for lupus, inhibits lupus progression
BackgroundPrevious studies reported that IL-38 was abnormally expressed in patients with systemic lupus erythematosus (SLE). However, the involvement...
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The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis
Type 2 innate lymphoid cells (ILC2s) have emerged as key regulators of the immune response in renal inflammatory diseases such as lupus nephritis....
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Daratumumab monotherapy for refractory lupus nephritis
Treatment-refractory lupus nephritis (LN) has a high risk of a poor outcome and is often life-threatening. Here we report a case series of six...
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Phosphopeptides P140 cause oxidative burst responses of pulmonary macrophages in an imiquimod-induced lupus model
Recent studies challenge the dogma that a 21-mer phosphopeptide P140 protects against direct cell damage in the phase-III clinical trial...
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B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation
Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source...
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Examination of the shared genetic architecture between multiple sclerosis and systemic lupus erythematosus facilitates discovery of novel lupus risk loci
Systemic Lupus Erythematosus (SLE) is an autoimmune disease with heterogeneous manifestations, including neurological and psychiatric symptoms....
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Th17 and Th1 cells in systemic lupus erythematosus with focus on lupus nephritis
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by T cells imbalance. Indeed, a correlation between levels of Th17...
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Lupus Anticoagulant Testing: Dilute Prothrombin Time (dPT)
Lupus anticoagulants (LA) rarely affect routine prothrombin time assays because the high phospholipid (PL) content in thromboplastin reagents tends...
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Anti-complement factor H (CFH) autoantibodies could delay pristane-induced lupus nephritis
PurposeAnti-complement factor H (CFH) autoantibodies could be detected in lupus and its significance remained to be elucidated. Herein, we aimed to...
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Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis
Lupus nephritis (LN) is a severe and common manifestation of systemic lupus erythematosus (SLE) that is frequently identified with a poor prognosis....
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Lupus Nephritis: New and Emerging Biologic and Targeted Therapies
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), a polyclonal systemic autoimmunity directed against nuclear and...
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Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway
Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentraxin 3 (PTX3) is highly...
