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Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis
Azithromycin was introduced in lung transplantation in an attempt to improve the pulmonary function in patients with chronic allograft dysfunction...
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Lung organoids: current strategies for generation and transplantation
Lung diseases occupy a leading position in human morbidity and are the third leading cause of death. Often the chronic forms of these diseases do not...
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Lung Transplantation under a Janus Kinase Inhibitor in Three Patients with SAVI Syndrome
Stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) is a very rare autoinflammatory disease related to STING1 ...
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α7nAChR Activation Combined with Endothelial Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis through the NF-κB Pathway
Chronic diabetes mellitus compromises the vascular system, which causes organ injury, including in the lung. Due to the strong compensatory ability...
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Exploratory associations of tacrolimus exposure and clinical outcomes after lung transplantation: A retrospective, single center experience
PurposeThis study aimed to investigate the potential impact of tacrolimus (TAC) exposure on clinical outcomes after lung transplantation.
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Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation
Hematopoietic cell transplantation (HCT) uses cytotoxic chemotherapy and/or radiation followed by intravenous infusion of stem cells to cure...
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On Target: An Intrapulmonary Transplantation Method for Modelling Lung Tumor Development in its Native Microenvironment
The development of in vivo lung cancer models that faithfully mimic the human disease is a crucial research tool for understanding the molecular...
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Assessment of NLRP3 inflammasome activation in patients with chronic obstructive pulmonary disease before and after lung transplantation
The interplay between purinergic receptors as well as pattern recognition receptors like Toll-like receptors (TLRs) and NOD-, LRR-, and pyrin...
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Immunosuppression in Lung Transplantation
Immunosuppression in lung transplantation is an area devoid of robust clinical data. This chapter will review the history of immunosuppression in...
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Metagenomic sequencing reveals time, host, and body compartment-specific viral dynamics after lung transplantation
BackgroundThe virome of lung transplant recipients (LTRs) under immunosuppressive therapy is dominated by non-pathogenic Anelloviridae and further...
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Association between time in therapeutic range of tacrolimus blood concentration and acute rejection within the first three months after lung transplantation
BackgroundTacrolimus is a key drug in immunosuppressive therapy following lung transplantation. The blood tacrolimus levels are likely to fluctuate...
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HLA in Transplantation
This chapter is about kidney and bone marrow transplantation, a therapy that is routinely used in our hospitals to correct a failure of different...
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Acellular ex vivo lung perfusate silences pro-inflammatory signaling in human lung endothelial and epithelial cells
BackgroundIschemia–reperfusion injury is a key complication following lung transplantation. The clinical application of ex vivo lung perfusion (EVLP)...
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Immunology of Transplantation and Malignancy
Successful transplantation requires a multitude of important steps: surgical asepsis, development of surgical techniques of vascular anastomosis,...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Predominantly defective CD8+ T cell immunity to SARS-CoV-2 mRNA vaccination in lung transplant recipients
BackgroundAlthough mRNA vaccines have overall efficacy preventing morbidity/mortality from SARS-CoV-2 infection, immunocompromised persons remain at...
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Intact lung tissue and bronchoalveolar lavage fluid are both suitable for the evaluation of murine lung microbiome in acute lung injury
BackgroundAccumulating clinical evidence suggests that lung microbiome is closely linked to the progression of pulmonary diseases; however, it is...
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Dual-color FISH analyses of xenogeneic human fibroblast sheets transplanted to repair lung pleural defects in an immunocompromised rat model
BackgroundPulmonary air leaks (PALs) due to visceral pleura injury during surgery is frequently observed after pulmonary resections and the...
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Synbiotics in Lung Cancer
Human microbiota has gained significant interest in the prevention and treatment of cancer. Synbiotics are profound examples of how microbiota can be...
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A case of successful contribution of therapeutic drug monitoring of valganciclovir as the prophylaxis against cytomegalovirus infection in a lung transplant recipient
BackgroundGanciclovir and its prodrug, valganciclovir, are first-line agents for cytomegalovirus infection prophylaxis after lung transplantation....
