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USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity
Lung squamous cell carcinoma (LUSC) is associated with high mortality and limited targeted therapies. USP13 is one of the most amplified genes in...
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The insufficiency of CT examination in early detection of central lung squamous cell carcinoma and squamous epithelial precancerous lesions
BackgroundCT examination for lung cancer has been carried out for more than 20 years and great achievements have been made in the early detection of...
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Impact of treatment interval between neoadjuvant immunochemotherapy and surgery in lung squamous cell carcinoma
ObjectiveThe optimal timing for surgery following neoadjuvant immunochemotherapy for lung squamous cell carcinoma appears to be a topic of limited...
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Bioinformatics Identification and Experimental Validation of a Prognostic Model for the Survival of Lung Squamous Cell Carcinoma Patients
Lung squamous cell carcinoma (LUSC) kills more than four million people yearly. Creating more trustworthy tumor molecular markers for LUSC early...
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Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma
BackgroundSquamous cell carcinoma (SqCC) is a subtype of non-small cell lung cancer for which patient prognosis remains poor. The extracellular...
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Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity....
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MUC1 promotes cervical squamous cell carcinoma through ERK phosphorylation-mediated regulation of ITGA2/ITGA3
In contrast to the decreasing trends in developed countries, the incidence and mortality rates of cervical squamous cell carcinoma in China have...
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OCT4’s role and mechanism underlying oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative...
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Advances in cutaneous squamous cell carcinoma
Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise transformation from healthy epithelium to premalignant...
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Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example
Compared with those in adenocarcinoma, PIK3CA mutations are more common in squamous cell carcinoma (SCC), which arises from stratified squamous...
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Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach
RelevanceThe proteasome is a crucial mechanism that regulates protein fate and eliminates misfolded proteins, playing a significant role in cellular...
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Reciprocal FGF19-GLI2 signaling induces epithelial-to-mesenchymal transition to promote lung squamous cell carcinoma metastasis
PurposeMetastatic lung squamous cell carcinoma (LUSC) is one of the most common causes of cancer death worldwide. As yet, however, the molecular...
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Cost-effectiveness of immunotherapies for advanced squamous non-small cell lung cancer: a systematic review
BackgroundThere are differences in the pharmacoeconomics of Immune checkpoint blocking (ICB) therapies for the treatment of lung squamous cell...
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Biomedical Approaches in the Research and Management of Head and Neck Squamous Cell Carcinoma
This chapter discusses emerging novel approaches for the molecular characterization of head and neck squamous cell carcinoma (HNSCC). The chapter...
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Preclinical models in head and neck squamous cell carcinoma
Head and neck cancer is the sixth most frequent cancer type. Drug resistance and toxicity are common challenges of the existing therapies, making the...
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M7G-Related lncRNAs predict prognosis and regulate the immune microenvironment in lung squamous cell carcinoma
BackgroundN7-Methylguanosine (m7G) and long non-coding RNAs (lncRNAs) have been widely studied in cancer and have been found to be useful for...
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RAD51 is a poor prognostic marker and a potential therapeutic target for oral squamous cell carcinoma
ObjectivesRAD51 overexpression has been reported to serve as a marker of poor prognosis in several cancer types. This study aimed to survey the role...
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Survival-associated N6-adenosine methyltransferase signatures in lung squamous cell carcinoma and clinical verification
BackgroundN 6 -methyladenine (m 6 A) is the most common modification of mRNA and IncRNA in higher organisms. m 6 A has been confirmed to be related to the...
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Online decision tools for personalized survival prediction and treatment optimization in elderly patients with lung squamous cell carcinoma: a retrospective cohort study
BackgroundDespite major advances in cancer therapeutics, the therapeutic options of Lung Squamous Cell Carcinoma (LSCC)-specific remain limited....
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Radiation-induced upregulation of FGL1 promotes esophageal squamous cell carcinoma metastasis via IMPDH1
BackgroundWhile radiation therapy remains pivotal in esophageal squamous cell carcinoma (ESCC) treatment, the perplexing phenomenon of post-radiation...
