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TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity
The transcription factor TRPS1 is a context-dependent oncogene in breast cancer. In the mammary gland, TRPS1 activity is restricted to the luminal...
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Circulating biomarkers at diagnosis correlate with distant metastases of early luminal-like breast cancer
There is an urgent need for new and better biomarker modalities to estimate the risk of recurrence within the luminal-like breast cancer (BC)...
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Evaluation of tumour infiltrating lymphocytes in luminal breast cancer using artificial intelligence
BackgroundTumour infiltrating lymphocytes (TILs) are a prognostic parameter in triple-negative and human epidermal growth factor receptor 2...
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An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2
PurposeLuminal breast cancer (BC) is a prevalent subtype associated with an increased risk of late disease recurrence and mortality. Long noncoding...
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Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits
Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these...
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Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion
BackgroundThe aberrant amplification of mammary luminal progenitors is at the origin of basal-like breast cancers associated with BRCA1 mutations....
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ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
PurposeTumor heterogeneity complicates patient treatment and can be due to transitioning of cancer cells across phenotypic cell states. This process...
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Sustained postconfluent culture of human mammary epithelial cells enriches for luminal and c-Kit+ subtypes
BackgroundA challenge in human mammary epithelial cell (HMEC) culture is sustaining the representation of competing luminal, myoepithelial, and...
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Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer
BackgroundAberrant expressions of desmoglein 2 (Dsg2) and desmocollin 2(Dsc2), the two most widely distributed desmosomal cadherins, have been found...
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Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice
Ketogenic diets (KDs) can improve the well-being and quality of life of breast cancer patients. However, data on the effects of KDs on mammary tumors...
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Distinct cervical tissue-adherent and luminal microbiome communities correlate with mucosal host gene expression and protein levels in Kenyan sex workers
BackgroundThe majority of studies characterizing female genital tract microbiota have focused on luminal organisms, while the presence and impact of...
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The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture
BackgroundThe active transport of molecules into the brain from blood is regulated by receptors, transporters, and other cell surface proteins that...
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Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature
Normal breast luminal epithelial progenitors have been implicated as cell of origin in basal-like breast cancer, but their anatomical localization...
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Pan-cancer onco-signatures reveal a novel mitochondrial subtype of luminal breast cancer with specific regulators
BackgroundSomatic alterations in cancer cause dysregulation of signaling pathways that control cell-cycle progression, apoptosis, and cell growth....
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GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer
In breast cancer patients, tumor heterogeneity is associated with prognosis and therapeutic response; however, the epigenetic diversity that exists...
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Quantitative Analysis of Presynaptic Vesicle Luminal pH in Cultured Neurons
Newly generated synaptic vesicles (SVs) are re-acidified by the activity of the vacuolar-type H+-ATPases. Since H+ gradient across SV membrane drives...
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The impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients
BackgroundThere is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We...
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Enhancing therapeutic efficacy in luminal androgen receptor triple-negative breast cancer: exploring chidamide and enzalutamide as a promising combination strategy
Extensive exploration of the molecular subtypes of triple-negative breast cancer (TNBC) is critical for advancing precision medicine. Notably, the...
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Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features
According to the classification presented by Lehmann BD (2016), triple-negative breast cancer (TNBC) is a heterogeneous group of malignant tumors...
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Promoter methylation of transient receptor potential melastatin-related 7 (TRPM7) predicts a better prognosis in patients with Luminal A breast cancers
Breast cancer is the most common female tumors arising worldwide, and genetic and epigenetic events are constantly accumulated in breast...
