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Cholesterol homeostasis and cancer: a new perspective on the low-density lipoprotein receptor
BackgroundDisturbance of cholesterol homeostasis is considered as one of the manifestations of cancer. Cholesterol plays an essential role in the...
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Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice
The E2 promoter binding factor 1 (E2F1) and the Wnt/β-catenin signaling are crucial in regulating metabolic homeostasis including obesity....
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Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer’s disease. YKL-40 is a...
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Circular RNA circ_0008896 contributes to oxidized low-density lipoprotein-induced aortic endothelial cell injury via targeting miR-188-3p/NOD2 axis
We aimed to investigate the role and mechanism of circ_0008896 in Atherosclerosis (AS) by using oxidized low-density lipoprotein (ox-LDL)-induced...
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Human cholesteryl ester transport protein transgene promotes macrophage reverse cholesterol transport in C57BL/6 mice and phospholipid transfer protein gene knockout mice
Cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) belong to the same gene family. Liver-specific expression of CETP...
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Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury
BackgroundInflammatory response has been recognized as a pivotal pathophysiological process during cerebral ischemic stroke. NLRP3 inflammasome,...
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MMP12 knockout prevents weight and muscle loss in tumor-bearing mice
BackgroundColorectal cancer is a malignant gastrointestinal cancer, in which some advanced patients would develop cancer cachexia (CAC). CAC is...
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Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins
Hyperlipidemia impacts millions of people globally and has been the major risk factor for develo** atherosclerosis and cardiovascular disease....
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Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling
Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) with various etiologies, which seriously affects the structure and...
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Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine
Berberine (BBR) is a Chinese herb with antioxidant and anti-inflammatory properties. In a previous study, we found that BBR had a protective effect...
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Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases
Scavenger Receptor Class F Member 2 ( SCARF2 ), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by...
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Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway
Diabetes-related vascular complications include diabetic cardiovascular diseases (CVD), diabetic nephropathy (DN) and diabetic retinopathy, etc. DN...
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Metrnl deficiency retards skin wound healing in mice by inhibiting AKT/eNOS signaling and angiogenesis
Meteorin-like (Metrnl) is a novel secreted protein with various biological activities. In this study, we investigated whether and how Metrnl...
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Poly(Butyl Cyanoacrylate) Nanoparticles Deliver β-Nerve Growth Factor to the Brain After Traumatic Brain Injury
Introduction Traumatic brain injury (TBI)Traumatic Brain Injury (TBI) is one of the main reasons for disability and death in patients. There is...
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Enhanced Peripheral Chemoreflex Drive Is Associated with Cardiorespiratory Disorders in Mice with Coronary Heart Disease
Coronary heart disease (CHD) is a prevalent cardiovascular disease characterized by coronary artery blood flow reductions caused by lipid deposition...
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LRP1 is a neuronal receptor for α-synuclein uptake and spread
BackgroundThe aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson’s...
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How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors
Vascular P2Y receptors mediate many effects, but the role of individual subtypes is often unclear. Here we discuss how subtype-selective antagonists...
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Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia
Pharmaceuticals and environmental contaminants contribute to hypercholesterolemia. Several chemicals known to cause hypercholesterolemia, activate...
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Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β
BackgroundCell adhesion is indispensable for appropriate tissue architecture and function in multicellular organisms. Besides maintaining tissue...
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Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking
Repeated exposure to opioids causes tolerance, which limits their analgesic utility and contributes to overdose and abuse liability. However, the...
