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Longitudinally aligned inner-patterned silk fibroin conduits for peripheral nerve regeneration
Peripheral nerve injuries represent a major clinical challenge, if nerve ends retract, there is no spontaneous regeneration, and grafts are required...
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Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
BackgroundIn utero exposure to maternal hyperglycemia has been associated with an increased risk for the development of chronic diseases in later...
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Immunological shifts during early-stage Parkinson’s disease identified with DNA methylation data on longitudinally collected blood samples
Parkinson’s disease (PD) is the second most common neurodegenerative disease in the United States. Decades before motor symptoms manifest, non-motor...
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Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease
BackgroundLow levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer’s...
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Elusive tuberculous meningitis with rare neurological complication of longitudinally extensive transverse myelitis: a case report
IntroductionLongitudinally extensive transverse myelitis (LETM) is inflammation of the spinal cord that spans three or more spinal segments. LETM is...
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Functional Anatomy of the Cerebellum
This chapter revises the neuronal connections and their functional consequences in the mammalian cerebellum based on a new understating of its basic... -
Outcome and risk of recurrence in a large cohort of idiopathic longitudinally extensive transverse myelitis without AQP4/MOG antibodies
BackgroundLongitudinally extensive transverse myelitis (LETM) is classically related to aquaporin (AQP4)-antibodies (Ab) neuromyelitis optica...
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Copy number variation at the 22q11.2 locus influences prevalence, severity, and psychiatric impact of sleep disturbance
BackgroundSleep disturbance is common, impairing, and may affect symptomatology in developmental neuropsychiatric disorders. Here, we take a...
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Microcomputed Tomography to Visualize and Quantify Fungal Infection Burden and Inflammation in the Mouse Lung Over Time
Pulmonary mycoses are an important threat for immunocompromised patients, and although current treatments are effective, they suffer from multiple... -
The role of the default mode network in longitudinal functional brain reorganization of brain gliomas
The study of patients after glioma resection offers a unique opportunity to investigate brain reorganization. It is currently unknown how the...
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Fiber-specific micro- and macroscopic white matter alterations in progressive supranuclear palsy and corticobasal syndrome
Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are characterized by progressive white matter (WM) alterations associated with...
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Predictive modelling of response to neoadjuvant therapy in HER2+ breast cancer
HER2-positive (HER2+) breast cancer accounts for 20–25% of all breast cancers. Predictive biomarkers of neoadjuvant therapy response are needed to...