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Hereditary Lobular Breast Cancer: A Newly Defined Syndrome
Germline CDH1 mutations were first identified in 1998 in families with a strong history of early-onset gastric cancer. Now, 25 years on, it appears...
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Hereditary Lobular Breast Cancer Syndrome: Role of Surgery
Hereditary lobular breast cancer is a novel and rare inherited syndrome, and it represents a multifaceted and fascinating clinical entity. In recent...
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Reporting on invasive lobular breast cancer in clinical trials: a systematic review
Invasive lobular breast cancer (ILC) differs from invasive breast cancer of no special type in many ways. Evidence on treatment efficacy for ILC is,...
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Identification of the Shared Gene Signatures and Biological Mechanisms in Hyperplastic Enlarged Lobular Units and Breast Cancer
Breast cancer is a common cancer worldwide. Hyperplastic enlarged lobular units (HELUs) are common changes in the breasts of adult women. HELUs may...
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Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers
The most frequent special histological type of breast cancer is represented by invasive lobular carcinoma (ILC), which makes up about 15% of all...
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Pathway-based signatures predict patient outcome, chemotherapy benefit and synthetic lethal dependencies in invasive lobular breast cancer
BackgroundInvasive Lobular Carcinoma (ILC) is a morphologically distinct breast cancer subtype that represents up to 15% of all breast cancers....
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Breast Cancer
Breast cancers are a major cause of mortality in females, on a par with lung and colon cancers. One topic in this chapter are the causes of breast...
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Tumor microenvironment and immune system preservation in early-stage breast cancer: routes for early recurrence after mastectomy and treatment for lobular and ductal forms of disease
BackgroundIntra-ductal cancer (IDC) is the most common type of breast cancer, with intra-lobular cancer (ILC) coming in second. Surgery is the...
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Defining features of hereditary lobular breast cancer due to CDH1 with magnetic resonance imaging and tumor characteristics
Women with germline pathogenic variants in CDH1 , which encodes E-cadherin protein, are at increased lifetime risk of invasive lobular carcinoma...
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Histologic tumor type as a determinant of survival in hormone receptor-positive, HER2-negative, pT1-3 invasive ductal and lobular breast cancer
PurposeThe aim of the study was to compare the difference in survival between invasive ductal (IDC) and lobular carcinoma (ILC).
Methods ...
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Immunotherapy in Breast Cancer
Breast cancer affects 12% of women worldwide. Although advances in systemic, surgical, and radiation therapy approaches will cure a large proportion...
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Tamoxifen or aromatase inhibitors with ovarian function suppression in pre-menopausal stage I-III lobular breast cancer
While adjuvant treatment with the selective-estrogen receptor modulator (SERM) tamoxifen has been the standard of care for pre-menopausal patients...
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Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon
Invasive lobular carcinoma (ILC) is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers....
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Circulating tumor cells in early lobular versus ductal breast cancer and their associations with prognosis
This is a secondary data analysis of the TIPPING study, which included 1,121 patients with stage I-III breast cancer who had enumeration of CTCs (by...
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Breast Cancer
Breast cancer is currently the most diagnosed cancer in the female population, with a prevalence of 1 in 8 women.
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Biosimilars in Breast Cancer
Breast cancer is a significant health concern globally, leading to maximum mortalities amongst women worldwide, which is 11.6% of all cancers...
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Effect of histological breast cancer subtypes invasive lobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials
BackgroundInvasive lobular breast carcinomas (ILC) have different histological features compared to non-special type carcinomas (NST), but the effect...
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The role of AKR1 family in tamoxifen resistant invasive lobular breast cancer based on data mining
BackgroundTamoxifen (TAM) resistance to invasive lobular cell carcinoma is a challenge for breast cancer treatment. This study explored the role of...
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Epigenetics of Breast Cancer
Epigenetic modulations of gene expression, post-transcriptional silencing of messenger RNA (mRNA), and post-translational modifications of protein...
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Hereditary Gastric and Breast Cancer Syndrome CDH1: One Genotype with Multiple Phenotypes
In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors....