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Immunotherapy in the Solid Organ Transplant Recipient
Checkpoint inhibitor immunotherapy has limited data in the immunosuppressed solid organ transplant recipient population as early use in this...
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Long-term survival from progressive multifocal leukoencephalopathy in living-donor liver transplant recipient with preformed donor-specific antibody
Intensive immunosuppression has enabled liver transplantation even in recipients with preformed donor-specific antibodies (DSA), an independent risk...
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Donor and recipient polygenic risk scores influence the risk of post-transplant diabetes
Post-transplant diabetes mellitus (PTDM) reduces allograft and recipient life span. Polygenic risk scores (PRSs) show robust association with greater...
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Reactivation of occult hepatitis B virus infection in a renal transplant recipient
We report a case of hepatitis B virus (HBV) reactivation in a renal transplant recipient. Reactivation manifested as an occult infection with...
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Switch from a ritonavir to a cobicistat containing antiretroviral regimen and impact on tacrolimus levels in a kidney transplant recipient
BackgroundSolid-organ transplantation due to end-stage organ disease is increasingly performed in people living with HIV. Despite improved transplant...
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High intra-patient variability of tacrolimus within post-operative 1 month predicted worse 1-year outcomes in pediatric liver transplant recipients
BackgroundThe pharmacokinetics of tacrolimus (TAC) show high intra-patient variability (IPV), which is associated with poor long-term outcomes...
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A unique case of Miller Fisher-Guillain-Barré overlap syndrome in a liver transplant recipient
Guillain-Barré syndrome (GBS) is an ascending demyelinating polyneuropathy often associated with recent infection. Miller Fisher syndrome represents...
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Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology
Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer. In addition to the common...
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Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-Term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study
Background Immunocompromised patients have lower seroconversion rate in response to COVID-19 vaccination. The aim...
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The influence of recipient SLCO1B1 rs2291075 polymorphism on tacrolimus dose–corrected trough concentration in the early period after liver transplantation
PurposeTo explore the relationship between rs2291075 polymorphism in SLCO1B1 gene, which encodes an influx transmembrane protein transporter, and...
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Recipient C7 rs9292795 genotype and the risk of hepatocellular carcinoma recurrence after orthotopic liver transplantation in a Han Chinese population
BackgroundComplement component(C7) gene has been shown to influence the prognosis in Hepatocellular carcinoma (HCC) patients. The association between...
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mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma
Sirolimus is a regularly applied immunosuppressant for patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Sirolimus...
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The pharmacogenetics of tacrolimus in renal transplant patients: association with tremors, new-onset diabetes and other clinical events
Our study is the first study to investigate the effect of SNPs in CYP3A5 , CYP3A4 , ABCB1 and POR genes on the incidence of tremors, nephrotoxicity,...
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Risk factors of early bacterial infection and analysis of bacterial composition, distribution and drug susceptibility after cadaveric liver transplantation
BackgroundThis study provided a theoretical basis for the clinical diagnosis and treatment of bacterial infection after liver transplantation through...
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Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside
Cell therapies are emerging as promising treatments for a range of liver diseases but translational bottlenecks still remain including: securing and...
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Cytomegalovirus drug resistance mutations in transplant recipients with suspected resistance
Resistant CMV infections are challenging complications after SOT and HSCT. Prompt recognition of ARMs is imperative for appropriate therapy. 108...
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Analysis of HIV quasispecies and virological outcome of an HIV D+/R+ kidney–liver transplantation
IntroductionTransplantation among HIV positive patients may be a valuable therapeutic intervention. This study involves an HIV D+/R+ kidney–liver...
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Poor outcomes of early recurrent post-transplant bloodstream infection in living-donor liver transplant recipients
Bloodstream infection (BSI) is a common complication after living-donor liver transplantation (LDLT). Some patients develop recurrent BSIs. We...
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Mouse Models of Renal Allograft Transplant Rejection: Methods to Investigate Chemokine–GAG Interaction and Therapeutic Blockade
Chemokine–glycosaminoglycan (GAG) interactions direct immune cell activation and invasion, e.g., directing immune cells to sites of infection or...
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Vascularized Islet Transplantation as Composite Islet-Kidney Grafts with Nanoparticle-Labeled Islets in Large Animal Preclinical Transplant Models
Although there are many patients with diabetes and end-stage renal failure (DM/ESRD) who would benefit from a transplantation strategy that addresses...