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Liver Carcinogenesis Methods and Protocols
This volume discusses the latest advancements in modern methodologies used to study liver carcinogenesis. The first half of this book describes...
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Generation of Liver Organoid
Although liver/hepatic organoids are reportedly generated from adult stem cells isolated from the liver, primary liver samples are hindered by their...
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Liver Cancer
Liver cancer is a major lethal malignancy worldwide. This chapter describes the molecular pathogenesis of the main histological subtype,...
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Extracellular Vesicles and Fatty Liver
Fatty liver is a complex pathological process caused by multiple etiologies. In recent years, the incidence of fatty liver has been increasing year...
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Segmentation of liver and liver lesions using deep learning
Segmentation of organs and lesions could be employed for the express purpose of dosimetry in nuclear medicine, assisted image interpretations, and...
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The Role of Complement Regulatory Proteins During Liver Homeostasis and Hepatitis C Virus-Related Liver Disease
Hepatitis C virus (HCV) infection is often difficult to diagnose in its early stages. Throughout the infection, HCV demonstrably increases complement...
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Genome Editing and Fatty Liver
Fatty liver disease is characterized as nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Fatty liver disease is one of the...
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Functions and Clinical Relevance of Liver-Derived Immunoglobulins
Liver is the largest internal organ of the body with vital functions. In addition to its endocrine and exocrine activities, liver also plays a...
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Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment
The liver has a remarkable regenerative capacity. Nevertheless, under chronic liver-damaging conditions, this capacity becomes exhausted, allowing...
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Maresin1 alleviates liver ischemia/reperfusion injury by reducing liver macrophage pyroptosis
BackgroundCell pyroptosis has a strong proinflammatory effect, but it is unclear whether pyroptosis of liver macrophages exacerbates liver tissue...
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Bipotent transitional liver progenitor cells contribute to liver regeneration
Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into...
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Impact of Liver Sympathetic Nervous System on Liver Fibrosis and Regeneration After Bile Duct Ligation in Rats
The sympathetic nervous system (SNS) affects many functions of the body. SNS fibers regulate many aspects of liver function, repair, and...
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Modeling a Liver-Stage Malaria
This chapter starts with problems in the use of the disease model in drug discovery and pre-clinical study. Then, it provides information on...
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Molecular and Cellular Basis of Liver Organoid
An organoid is derived from multipotent stem cells that could be obtained from tissues of adults or fetuses and pluripotent stem cells. Thus, this...
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The gut-liver axis: emerging mechanisms and therapeutic approaches for nonalcoholic fatty liver disease and type 2 diabetes mellitus
Nonalcoholic fatty liver disease (NAFLD), more appropriately known as metabolic (dysfunction) associated fatty liver disease (MAFLD), a prevalent...
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Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment
Colorectal cancer (CRC) patients frequently develop liver metastases, which are the major cause of cancer-related mortality. The molecular basis and...
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Associations of perfluoroalkyl substances with metabolic-associated fatty liver disease and non-alcoholic fatty liver disease: NHANES 2017–2018
ObjectivesThis study investigated the potential effects of perfluoroalkyl substance (PFAS) in serum on MAFLD, NAFLD, and liver fibrosis.
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Single-Cell Characterization of the Tumor Ecosystem in Liver Cancer
Tumor heterogeneity along with the complex landscape of the tumor microenvironment create critical challenges for effective liver cancer...
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Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Hepatocellular carcinoma (HCC), one of the most prevalent forms of cancer worldwide, presents a significant global healthcare challenge. Cancer stem...
