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Binding and Characterization of DNA Origami Nanostructures on Lipid Membranes
DNA origami is an extremely versatile nanoengineering tool with widespread applicability in various fields of research, including membrane physiology...
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Regulation of Alternative Splicing of Lipid Metabolism Genes in Sepsis-Induced Liver Damage by RNA-Binding Proteins
RNA binding proteins (RBPs) have the potential for transcriptional regulation in sepsis-induced liver injury, but precise functions remain unclear....
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Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
To elicit optimal immune responses, messenger RNA vaccines require intracellular delivery of the mRNA and the careful use of adjuvants. Here we...
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Radioligand Binding at Muscarinic Receptors
Five subtypes of muscarinic acetylcholine receptors denoted M1 through M5 mediate a wide array of physiological functions. Therefore, impairment of...
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Function of lipid binding proteins of parasitic helminths: still a long road
Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases in humans and domestic animals on a global scale. Unable...
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Lipid-Related Pathophysiology of ASD
Autism spectrum disorder (ASD) is the unitary diagnostic classification for a heterogeneous neurodevelopmental disorder characterized by deficits in...
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Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is strongly associated with obesity-related ectopic...
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Ligand binding at the protein–lipid interface: strategic considerations for drug design
Many drug targets are embedded within the phospholipid bilayer of cellular membranes, including G protein-coupled receptors, ion channels,...
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Restoration of HMGCS2-mediated ketogenesis alleviates tacrolimus-induced hepatic lipid metabolism disorder
Tacrolimus, one of the macrolide calcineurin inhibitors, is the most frequently used immunosuppressant after transplantation. Long-term...
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ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA...
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MEF2C regulates NK cell effector functions through control of lipid metabolism
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare mutations in a small subset of transcription factors can...
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Lipid metabolism: the potential targets for toxoplasmosis treatment
Toxoplasmosis is a zoonosis caused by Toxoplasma gondii ( T. gondii ). The current treatment for toxoplasmosis remains constrained due to the absence...
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TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway
Macrophage lipid accumulation is a critical contributor to foam cell formation and atherosclerosis. Tumor necrosis factor-α-induced protein 1...
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Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and has a great socio-economic impact. Modified oxidative lipid...
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Identification of the Lipid Antigens Recognized by rHIgM22, a Remyelination-Promoting Antibody
Failure of the immune system to discriminate myelin components from foreign antigens plays a critical role in the pathophysiology of multiple...
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Lipid droplets in pathogen infection and host immunity
As the hub of cellular lipid metabolism, lipid droplets (LDs) have been linked to a variety of biological processes. During pathogen infection, the...
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Nuclear Receptors and Lipid Sensing
Fluctuations in concentration of diverse lipid classes occur in response to diet and metabolism. These changes are managed and mediated by a cell...
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Lipid Microparticles Show Similar Efficacy With Lipid Nanoparticles in Delivering mRNA and Preventing Cancer
PurposeMessenger RNA (mRNA) has shown great promise for vaccine against both infectious diseases and cancer. However, mRNA is unstable and requires a...
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HDL and Lipid Metabolism
Mediating reverse cholesterol transport (RCT) is the most classic function of HDL. HDL and HDL-C participate in the entire process of RCT, including...
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Solid Lipid Nanoparticles for the Management of Allergic Airway Diseases
The allergic airway diseases comprise both allergic rhinitis and asthma which are amongst the top three ailments of the twenty-first century...