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ThPOK is a critical multifaceted regulator of myeloid lineage development
The transcription factor ThPOK (encoded by Zbtb7b ) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, we...
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Multi-lineage Differentiation from Hematopoietic Stem Cells
The hematopoietic stem cells (HSCs) have the ability to differentiate and give rise to all mature blood cells. Commitment to differentiation...
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Lineage and sublineage analysis of human papillomavirus types 51 and 59 in Iranian women
The current study aimed to investigate the sequence variations of HPV 51 and 59 in normal cervical cells and premalignant/malignant lesions of the...
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USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity
Lung squamous cell carcinoma (LUSC) is associated with high mortality and limited targeted therapies. USP13 is one of the most amplified genes in...
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Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report
BackgroundThe COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 virus, emerged in late 2019 and spready globally. Many...
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Single-cell multiomic analysis of thymocyte development reveals drivers of CD4+ T cell and CD8+ T cell lineage commitment
The development of CD4 + T cells and CD8 + T cells in the thymus is critical to adaptive immunity and is widely studied as a model of lineage...
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Grave-to-cradle: human embryonic lineage tracing from the postmortem body
Curiosity concerning the process of human creation has been around for a long time. Relevant questions seemed to be resolved with the knowledge of...
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Global mpox lineage discovery and rapid outbreak tracking with nanopore sequencing
Insufficient tracking of virus introduction, spread, and new lineage emergence for the human monkeypox (mpox) virus 1 (hMPXV1) outbreak of 2022...
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Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum
Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic and GABAergic axons and can be dynamically regulated by...
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Genomic loss of the HSP70cA gene in the vertebrate lineage
Metazoan 70 kDa heat shock protein (HSP70) genes have been classified into four lineages: cytosolic A ( HSP70cA ), cytosolic B ( HSP70cB ), endoplasmic...
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Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland
The pituitary gland is a major endocrine tissue composing of two distinct entities, the adenohypophysis (anterior pituitary, cranial placode origin)...
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A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells
SATB1 (Special A-T rich Binding protein 1) is a cell type-specific factor that regulates the genetic network in develo** T cells and neurons. In T...
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Longitudinal tracking of hemocyte populations in vivo indicates lineage relationships and supports neural progenitor identity in adult neurogenesis
Adult neurogenesis, which takes place in both vertebrate and invertebrate species, is the process by which new neurons are born and integrated into...
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Evolution and divergence of the genetic lineage Desmodus rotundus/Artibeus lituratus of rabies virus in São Paulo State
The last record of a rabies case caused by the dog-specific rabies virus (RABV) lineage in dogs or cats in São Paulo State was in 1998. From 2002 to...
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Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage
Prdm12 is an epigenetic regulator expressed in develo** and mature nociceptive neurons, playing a key role in their specification during...
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Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo
Outbreaks of monkeypox (mpox) have historically resulted from zoonotic spillover of clade I monkeypox virus (MPXV) in Central Africa and clade II...
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Machado-Joseph disease in a Sudanese family links East Africa to Portuguese families and allows reestimation of ancestral age of the Machado lineage
Machado-Joseph disease (MJD/SCA3) is the most frequent dominant ataxia worldwide. It is caused by a (CAG) n expansion. MJD has two major ancestral...
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X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consuming and low throughput. We...
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MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles...
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Paternal aging impacts expression and epigenetic markers as early as the first embryonic tissue lineage differentiation
BackgroundAdvanced paternal age (APA) is associated with adverse outcomes to offspring health, including increased risk for neurodevelopmental...
