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Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have obvious advantages over MSC therapy. But the strong procoagulant properties of...
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Miscarriage risk assessment: a bioinformatic approach to identifying candidate lethal genes and variants
PurposeMiscarriage, often resulting from a variety of genetic factors, is a common pregnancy outcome. Preconception genetic carrier screening (PGCS)...
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Modifiable risk factors for subsequent lethal prostate cancer among men with an initially negative prostate biopsy
BackgroundPreviously suggested modifiable risk factors for prostate cancer could have resulted from detection bias because diagnosis requires a...
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Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes
BackgroundThe genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide...
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Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning
IntroductionCyanide exposure can occur in various settings such as industry and metallurgy. The primary mechanism of injury is cellular hypoxia from...
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The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ
Cytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive...
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Lethal and sublethal impacts of membrane-fed ivermectin are concentration dependent in Anopheles coluzzii
BackgroundIvermectin is a well-tolerated anthelminthic drug with wide clinical and veterinary applications. It also has lethal and sublethal effects...
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YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge
Ebola virus (EBOV) and related filoviruses such as Sudan virus (SUDV) threaten global public health. Effective filovirus vaccines are available only...
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Sub-lethal exposure to chlorfenapyr reduces the probability of develo** Plasmodium falciparum parasites in surviving Anopheles mosquitoes
BackgroundPyrethroid resistance in the key malaria vectors threatens the success of pyrethroid-treated nets. To overcome pyrethroid resistance,...
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Transcriptional changes in multiple endocrine organs from lethal cases of COVID-19
AbstractAltered circulating hormone and metabolite levels have been reported during and post-COVID-19. Yet, studies of gene expression at the tissue...
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A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019 (COVID-19)...
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In-vitro susceptibility and ex-vivo evaluation of macrocyclic lactone endectocides sub-lethal concentrations against Plasmodium vivax oocyst development in Anopheles arabiensis
BackgroundAsymptomatic malaria transmission has become a public health concern across malaria-endemic Africa including Ethiopia. Specifically, Plasmod...
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Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
BackgroundMacrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and...
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CRISPR-cas9 screening identified lethal genes enriched in Hippo kinase pathway and of predictive significance in primary low-grade glioma
BackgroundLow-grade gliomas (LGG) are a type of brain tumor that can be lethal, and it is essential to identify genes that are correlated with...
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Non-lethal Raine Syndrome Report Lacking Characteristic Clinical Features
Raine syndrome is a rare, often lethal autosomal recessive condition marked by congenital malformations that range in severity. Considering that...
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Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer
BackgroundThe majority of BRCA1 -mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype,...
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Aurora kinase A, a synthetic lethal target for precision cancer medicine
Recent advances in high-throughput sequencing technologies and data science have facilitated the development of precision medicine to treat cancer...
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Ebola Virus Disease: An Emerging Lethal Disease in Africa
Ebola virus, a member of filovirus family, is the causative agent of Ebola Virus Disease. Since the first incidence of the disease near the Ebola...
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Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection
As the resident parenchymal myeloid population in the central nervous system (CNS), microglia are strategically positioned to respond to neurotropic...
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Generation of a lethal mouse model expressing human ACE2 and TMPRSS2 for SARS-CoV-2 infection and pathogenesis
Mouse models expressing human ACE2 for coronavirus disease 2019 have been frequently used to understand its pathogenesis and develop therapeutic...
