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Investigation of cardioprotective effect of lercanidipine on doxorubicin-induced cardiotoxicity
Although doxorubicin (DOX) is an effective anti-neoplastic drug for many types of cancer, particularly dose-related cardiotoxicity limits the use of...
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Lercanidipine alleviates doxorubicin-induced lung injury by regulating PERK/CHOP and Bax/Bcl 2/Cyt c pathways
Doxorubicin (DOX), which is used to treat various cancers and hematological malignancies, has limited therapeutic application due to its toxicity in...
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Exploratory Study on Lercanidipine Hydrochloride Polymorphism: pH-Dependent Solubility Behavior and Simulation of its Impact on Pharmacokinetics
This work describes an exploratory experimental and in silico study of the influence of polymorphism, particle size, and physiology on the...
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Nasal Mucoadhesive Microspheres of Lercanidipine with Improved Systemic Bioavailability and Antihypertensive Activity
PurposeThe current study entails the design, development, and optimization of nasal mucoadhesive microspheres of lercanidipine with improved systemic...
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A Design-assisted Spectrofluorometric Method Utilizing a One-pot Fluorescent Probe for the Quantitation of some Calcium Channel Blockers
Based on their reaction with highly fluorescent carbon quantum dots (CQDts), a precise and reliable spectrofluorometric approach was developed for...
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A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization
Poor bioavailability of drugs via oral route is the greatest challenge facing drug formulation. To overcome this obstacle, transdermal route was...
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Paraptosis: a non-classical paradigm of cell death for cancer therapy
Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential strategy for cancer therapy. Paraptosis is a mode of...
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Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital
BackgroundDialysis patients are at high risk for drug-related problems (DRPs), which have significant consequences for their morbidity, mortality,...
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Correction to: A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization
In the original article, there are errors in Tables 2 and 6. Following are the corrected tables.
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Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives
Gastric cancer remains an important contributor to the global cancer burden ranking the 5th most common and the 4th most deadly cancer, according to...
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Polypharmacology in Clinical Applications: Renal Polypharmacology
The urinary system, also known as the renal system or urinary tract, consists of the kidneys ,...
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Studies on the mechanisms of action of MR33317
MR33317 was synthesized as an acetylcholinesterase-inhibitor and an agonist at brain 5-HT 4 -receptors. MR33317 might be used to treat Morbus...
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Polygenic scores for cardiovascular risk factors improve estimation of clinical outcomes in CCB treatment compared to pharmacogenetic variants alone
Pharmacogenetic variants are associated with clinical outcomes during Calcium Channel Blocker (CCB) treatment, yet whether the effects are modified...
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Harmonization of summaries of product characteristics (SmPCs) of drugs with the same active ingredients: an evaluation of SmPCs of the most frequently prescribed active substances
PurposeIn aut-idem or generic substitution, discrepancies between summaries of product characteristics (SmPCs) referring to the same active substance...
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Recent Applications of Quantum Dots in Pharmaceutical Analysis
Nanotechnology has emerged as one of the most potential areas for pharmaceutical analysis. The need for nanomaterials in pharmaceutical analysis is...
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Duplicate prescriptions in the emergency department: a retrospective cohort study
PurposeTo determine the nature and frequency of duplicate prescriptions (DPs) in the emergency department (ED) by utilization of a novel...
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Ifosfamide-induced encephalopathy: the EEG with frontal intermittent delta activity, and rapid resolution with methylene blue: A case report
BackgroundEncephalopathy is an established side effect of the chemotherapeutic agent, ifosfamide, occurring in 10–30% of cases. The EEG commonly...
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The combined effects of telmisartan and ramipril on hypertension and cardiovascular injury
PurposeMore than half of hypertensive patients receive combination therapy with two or more drugs. For combination therapy with antihypertensive...
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Response Surface Designs and Their Applications in Pharmaceutical Development
The response surface methodology (RSM) requires high-resolution designs which are particularly useful for the optimization purpose. It is now...