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Correlation of the Left Ventricular Systolic Dysfunction and Ventricular Depolarization in a Post-Infarction Model of Chronic Heart Failure
The body surface potential map** of the heart during the period of ventricular depolarization and the inotropic function of the ventricles were...
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A Heterozygous Phospholamban Variant (p.R14del) Leads to Left Ventricular Involvement and Heart Failure Phenotypes in Arrhythmogenic Right Ventricular Cardiomyopathy
This study aimed to determine the prevalence and clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) caused by pathogenic...
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Porcine Model of Hypertrophy-Independent Left Ventricular Stiffening via Repetitive Pressure Overload
Diastolic dysfunction arising from alterations in myocardial structure and/or function is a central component of several cardiovascular disorders,...
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Arrhythmogenic left ventricular cardiomyopathy caused by a novel likely pathogenic DSP mutation, p.K1165Rfs*8, in a family with sudden cardiac death
ObjectiveWe conducted an investigation into the clinical and molecular characteristics of Arrhythmogenic left ventricular cardiomyopathy (ALVC)...
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Effect of p-Tyrosol on the Process of Left-Ventricular Remodeling in the Long Period after Myocardial Infarction
The effect of p -tyrosol on the main hemodynamic parameters and contractile function of the heart was studied and a morphometric assessment of...
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Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development
Coronary Artery Fistulae (CAFs) are cardiac congenital anomalies consisting of an abnormal communication of a coronary artery with either a cardiac...
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Role of Early Left Atrial Functional Decline in Predicting Cardiotoxicity in HER2 Positive Breast Cancer Patients Treated With Trastuzumab
Trastuzumab is widely used in HER2 breast cancer. However, it may cause left ventricular (LV) dysfunction. A decrease in LV global longitudinal...
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GSDMD-mediated pyroptosis dominantly promotes left ventricular remodeling and dysfunction in post-myocardial infarction: a comparison across modes of programmed cell death and mitochondrial involvement
BackgroundMyocardial infarction (MI) has recently accounted for more than one-third of global mortality. Multiple molecular pathological pathways,...
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Tumors of Choroid Plexus and Other Ventricular Tumors
Tumors arising inside the ventricular system are rare but represent a difficult diagnostic and therapeutic challenge. They usually are diagnosed when...
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Aortic disease and cardiomyopathy in patients with a novel DNMT3A gene variant causing Tatton-Brown–Rahman syndrome
Tatton-Brown–Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic variants in the DNA...
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Noninvasive and Invasive Study of the Pum** Function of Rat Heart in Myocardial Infarction
The cardiohemodynamics was studied 2 and 4 weeks after myocardial infarction modeling in Wistar rats. We compared the data obtained by...
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Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human
BackgroundDilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and...
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Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction
Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis...
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DSP p.(Thr2104Glnfs*12) variant presents variably with early onset severe arrhythmias and left ventricular cardiomyopathy
BackgroundDilated cardiomyopathy (DCM) is a condition characterized by dilatation and systolic dysfunction of the left ventricle in the absence of...
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Role of the T-Tubules in the Control of Cellular Calcium and Inotropic Interventions in Cardiac Ventricular Myocytes
The sarcolemma of mammalian cardiac ventricular myocytes contains a system of invaginations known as transverse (or t-) tubules that arise through...
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Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia
Idiopathic normal pressure hydrocephalus (iNPH) is considered an age-dependent chronic communicating hydrocephalus associated with cerebrospinal...
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Clinical Presentation and Therapy of Tetralogy of Fallot and Double-Outlet Right Ventricle
Tetralogy of Fallot (TOF) is the most common cyanotic heart defect. TOF consists of the combination of four anomalies (Fig. 35.1): (1) a large...
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Clinical Presentation and Therapy of d-Transposition of the Great Arteries
d-Transposition of the great arteries (d-TGA) is the most common form of congenital heart disease that presents with cyanosis in a newborn. The aorta...
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Clinical Presentation and Therapy of Truncus Arteriosus
Truncus arteriosus (TA, also known as common arterial trunk) consists of only one great artery (“the truncus”) with a semilunar valve (truncus valve)...
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Prediction of Ventricular Mechanics After Pulmonary Valve Replacement in Tetralogy of Fallot by Biomechanical Modeling: A Step Towards Precision Healthcare
Clinical indicators of heart function are often limited in their ability to accurately evaluate the current mechanical state of the myocardium....
