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Learned Helplessness in Rodents
Learned helplessness (LH) is a well-known phenomenon described in animals upon their exposure to uncontrollable and unpredictable aversive stimuli,...
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The Effect of Sericin on the Cognitive Impairment, Depression, and Anxiety Caused by Learned Helplessness in Male Mice
Learned helplessness (LH) induces cognitive and emotional abnormalities via alteration of synaptic and apoptotic markers in the hippocampus. Given...
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Systematic Input–Output Map** Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness
A common phenomenon called social buffering (SB), communication within conspecific animals is a benefit for a stressed individual to better recover...
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Assessment of Susceptibility of Outbred Albino Rats to the Formation of Depression-Like State of Learned Helplessness
Learned helplessness (a model of depression-like state) was developed in rats by exposure to repeated inescapable electric stimulation and evaluated...
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Th17 cells sense microbiome to promote depressive-like behaviors
BackgroundMicrobiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance...
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The alterations of glutamate transporter 1 and glutamine synthetase in the rat brain of a learned helplessness model of depression
BackgroundAlthough glutamate transmission via astrocytes has been proposed to contribute to the pathophysiology of depression, the precise mechanisms...
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Diet-based avoidance implications in rats in the conditional association with aversive stimuli
The growing number of overweight and obese individuals is a serious medical and social problem. On the one side, calories are important for our...
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Sex differences in anxiety and depression: circuits and mechanisms
Epidemiological sex differences in anxiety disorders and major depression are well characterized. Yet the circuits and mechanisms that contribute to...
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Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF
Curculigoside (CUR) is the main active component of traditional Chinese medicine Curculigoorchioides Gaertn (**anmao in Chinese), which exhibits a...
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The Role of Glucocorticoid Hormones in the Stress-Protective Effects of Hypoxic Postconditioning in Models of Depression and Post-Traumatic Stress Disorder in Rats
The effects of using neuroprotective hypoxic hypobaric postconditioning (PostC) were studied in two experimental models: stress-restress...
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Translational Strategies for Develo** Biomarkers for Major Depression: Lessons Learned from Animal Models
This review critically assesses the types of rodent models which have been developed in the search for new antidepressants. In order to determine the...
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Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice
BackgroundMajor depressive disorder is a widespread mood disorder. One of the most debilitating symptoms patients often experience is cognitive...
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Electrolytic lesions of the bilateral ventrolateral orbital cortex not only directly reduce depression-like behavior but also decreased desperate behavior induced by chronic unpredicted mild stress in rats
BackgroundPrevious studies have revealed that ventrolateral orbital cortex (VLO) may play an important role in the regulation of emotional behavior....
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Our child’s TBI: a rehabilitation engineer’s personal experience, technological approach, and lessons learned
I (JS) am currently a faculty member at The University of Texas at Austin in Mechanical Engineering. My primary research focus is rehabilitation...
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A rat model of operant negative reinforcement in opioid-dependent males and females
Rationale and objectiveAvoidance of opioid withdrawal plays a key role in human opioid addiction. Here, we present a procedure for studying operant...
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Serotonin and Dopamine in Biological Models of Depression
Depression in the biological models considered here can be split into two opposite patterns of changes in serotonin and dopamine levels,...
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Preconditioning by Moderate Hypoxia Increases the Amount of Corticosteroid Receptors in the Rat Brain in a Model of Depression
Abstract —The involvement of corticosteroid brain receptors in the antidepressant-like effects of moderate hypobaric hypoxia was studied in a rat...
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Effects of Various Interval Hypoxic Training Regimens in Experimental Models of Anxious-Depressive States in Rats
The development of non-drug-based methods for correcting stress-induced disorders and improving adaptation to stress remains an urgent task in...
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Effects of inescapable stress on responses to social incentive stimuli and modulation by escitalopram
RationaleStress is a well-known risk factor for anhedonia, and its impacts on social reward functions may be mitigated by its controllability....
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Animal Models of Mood and Anxiety Disorders: The Pursuit of Standardization and Recognition of the Complex Neurobiology of Human Mental Health
The research field of psychiatric animal modeling has ever been striving toward better validation of tests and models, and this includes attempts to...