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LINE-1 transcription activates long-range gene expression
Long interspersed nuclear element-1 (LINE-1 or L1) is a retrotransposon group that constitutes 17% of the human genome and shows variable expression...
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Methylation of the Retrotransposon LINE-1 Subfamilies in Chorionic Villi of Miscarriages
AbstractMiscarriage is potentially associated with abnormal epigenetic regulation of genes responsible for the development of the embryo and...
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RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5′-UTR
BackgroundType 1 long interspersed elements, or LINE-1, are the only retroelements that replicate autonomously in human cells. The retrotransposition...
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LINE-1 retrotransposons contribute to mouse PV interneuron development
Retrotransposons are mobile DNA sequences duplicated via transcription and reverse transcription of an RNA intermediate. Cis -regulatory elements...
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LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer
Background and purposeCurrently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and...
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Deep learning based digital pathology for predicting treatment response to first-line PD-1 blockade in advanced gastric cancer
BackgroundAdvanced unresectable gastric cancer (GC) patients were previously treated with chemotherapy alone as the first-line therapy. However, with...
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LINE-1 Methylation Index Correlates with Sister Chromatid Exchanges and Chromatid but Not Chromosome Aberrations in Personnel from a Nuclear Chemical Facility with Incorporated Plutonium-239
AbstractThe level of chromosomal abnormalities in the somatic cells of adult individuals is characterized by significant interindividual variability,...
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LINE-1 global DNA methylation, iron homeostasis genes, sex and age in sudden sensorineural hearing loss (SSNHL)
BackgroundSudden sensorineural hearing loss (SSNHL) is an abrupt loss of hearing, still idiopathic in most of cases. Several mechanisms have been...
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PD-1 inhibitors combined with paclitaxel and cisplatin in first-line treatment of esophageal squamous cell carcinoma (ESCC): a network meta-analysis
BackgroundThe combinations of PD-1 inhibitors with paclitaxel/cisplatinum (PD-1 + TP) and fluoropyrimidine/cisplatinum (PD-1 + FP) both have been...
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Pan cancer characterization of genes whose expression has been associated with LINE-1 antisense promoter activity
BackgroundLong interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As the only autonomous and active retrotransposons,...
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The Level of LINE-1 mRNA Is Increased in Extracellular Circulating Plasma RNA in Patients with Colorectal Cancer
We performed a comparative quantitative analysis of LINE-1 mRNA levels in extracellular total plasma RNA in patients with colon cancer and...
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Efficacy and safety of anti-PD-1 inhibitor versus anti-PD-L1 inhibitor in first-line treatment of extensive-stage small cell lung cancer: a multicenter retrospective study
BackgroundImmunotherapy targeting PD-1/PD-L1 has revolutionized the treatment of extensive-stage small cell lung cancer (ES-SCLC). However, clinical...
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Smoking and colorectal cancer survival in relation to tumor LINE-1 methylation levels: a prospective cohort study
BackgroundCarcinogens in cigarette smoke may cause aberrant epigenomic changes. The hypomethylation of long interspersed nucleotide element-1...
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An intronic LINE-1 regulates IFNAR1 expression in human immune cells
BackgroundDespite their origins as selfish parasitic sequences, some transposons in the human genome have been co-opted to serve as regulatory...
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Biallelic CC2D2A variants, SNV and LINE-1 insertion simultaneously identified in siblings using long-read whole-genome sequencing and haplotype phasing
Joubert syndrome (JBTS) is characterized by a magnetic resonance imaging appearance called ‘molar tooth sign’, neonatal breathing dysregulation and...
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A phase Ib/II study of cadonilimab (PD-1/CTLA-4 bispecific antibody) plus anlotinib as first-line treatment in patients with advanced non-small cell lung cancer
BackgroundCadonilimab is a bispecific antibody that simultaneously targets programmed cell death receptor-1 and cytotoxic T lymphocyte-associated...
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Unbiased proteomic map** of the LINE-1 promoter using CRISPR Cas9
BackgroundThe autonomous retroelement Long Interspersed Element-1 (LINE-1) mobilizes though a copy and paste mechanism using an RNA intermediate...
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The value of oral selective estrogen receptor degraders in patients with HR-positive, HER2-negative advanced breast cancer after progression on ≥ 1 line of endocrine therapy: systematic review and meta-analysis
BackgroundCurrently, the value of oral selective estrogen receptor degraders (SERDs) for hormone receptor-positive (HR+) and human epidermal growth...
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Locus-Specific DNA Methylation Profiling of Human LINE-1 Retrotransposons
Long Interspersed Element 1 (LINE-1 or L1) retrotransposons are the only active and autonomous mobile genetic elements present in the human genome....
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De Novo Somatic Mosaicism of CYBB Caused by Intronic LINE-1 Element Insertion Resulting in Chronic Granulomatous Disease
Chronic granulomatosis disease (CGD) is a rare inborn error of immunity, characterized by phagocytic respiratory outbreak dysfunction. Mutations...
