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Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction
Rationale and ObjectivesAddiction is defined as a chronically relapsing disorder characterized by compulsive drug seeking that is hypothesized to...
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Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis
Patients with a diagnosis of multiple sclerosis (MS) or major depressive disorder (MDD) share a wide array of biological abnormalities which are...
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Role of noradrenaline in the development of dopamine-induced hyperprolactinemia
Hyperprolactinemia is neurodegenerative disease that develops in humans as a result of degeneration of dopaminergic (DA-ergic) neurons of the arcuate...
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GABAB Receptor ad a Potential Therapeutic Target
At present, the only therapeutic agent in current use that is known to exert its effects through the GABA-B receptor is baclofen, the β-chlorophenyl...
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Modeling Human Anxiety and Depression in Mutant Mice
Mood and anxiety disorders represent some of the most common and proliferating health problems worldwide, but are inadequately treated by existing...
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The Canine Model of Narcolepsy
Although the canine narcoleptic model significantly contributed to the understanding of the etiological and pathophysiological aspects of the...
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5,7-Dihydroxytryptamine: Regional Brain Concentrations Following Intraventricular Administration to Rats
The concentrations of 5,7-dihydroxytryptamine (5,7-DHT) and serotonin (5-HT) were measured in brainstem, hypothalamus and cerebral cortex 0, 2, 6,...
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Neurotoxic Effects of Substituted Amphetamines in Rats and Mice
Whether you read about it in the popular press or in the scientific literature, there is no lack of coverage of the issue of amphetamine-induced...
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Synaptosomes Still Viable after 25 Years of Superfusion
Superfused synaptosomes have been utilized in studies of neurotransmitter release during 25 years. This review summarizes the aspects of...
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Different effects of 5-HT1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naive and stressed mice: a study using the hole-board test
Objectives: The effects of 5-HT 1A receptor agonists on the emotional behavior of naive or stressed mice were examined and compared with those of...
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Antiparkinsonian and neuroprotective effects of modafinil in the mptp-treated common marmoset
The psychostimulant drug, modafinil, protects rodents against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity, striatal ischemia and...
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Comparison of either norepinephrine-uptake inhibitors or phentermine combined with serotonergic agents on food intake in rats
Rationale: We have shown previously that the anorectic effects of the catecholamine-releasing agent phentermine (PHEN) and the serotonin...
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Serotonin depletion attenuates cocaine-seeking behavior in rats
Rationale: Alterations in serotonin (5-HT) neurotransmission during cocaine withdrawal may be involved in incentive motivation for cocaine. Objective: ...
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Metabolism, Pharmacogenetics, and Metabolic Drug–Drug Interactions of Antipsychotic Drugs
1. Antipsychotic drugs are extensively metabolised by cytochrome P450 (CYP) enzymes.
2. Dispositions of a number of antipsychotic drugs have been...
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Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat – interactions between the two drugs
Rationale: Withdrawal from chronic amphetamine administration is characterized by deficits in reward that resemble some symptoms of depression....
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Corticotropin-releasing factor antagonist attenuates the “anxiogenic-like” effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats
Rationale : Chronic cocaine abuse is associated with the development of anxiogenic states in humans. Corticotropin-releasing factor (CRF) is an...
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Effects of antidepressant drugs on the dopamine D2/D3 receptors in the rat brain differentiated by agonist and antagonist binding – an autoradiographic analysis
In the present study the effect of antidepressant drugs on the density of dopamine D 2 /D 3 receptors in the rat forebrain was examined using...
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Withdrawal following repeated exposure to d-amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement
Numerous studies have shown that withdrawal from sustained high doses of psychostimulant drugs such as cocaine or d -amphetamine produces...
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The effect of chronic administration of antidepressants on the circadian pattern of corticosterone in the rat
Although antidepressant administration has been reported to alter the pituitary–adrenal (PA) axis, the results are puzzling. In the present work,...