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Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure
BackgroundCombination antiretroviral therapy (cART) has dramatically extended the life expectancy of people living with HIV-1 and improved their...
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An Imaging Flow Cytometry Method for Assessment of Human Natural Killer Cells
Use of laser imaging flow cytometry for assessment of surface markers of human natural killer cells is considered. Cells were extracted from healthy...
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Innate lymphoid cells and innate-like T cells in cancer — at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for many cancers, yet only a subset of patients benefit from...
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Immunotherapy for Primary Cancers of Central Nervous System
Primary CNS tumors, despite many advancements in the field of neurosurgery and radio-oncology, have remained universally lethal. Although, until a...
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Role of beta-(1→3)(1→6)-D-glucan derived from yeast on natural killer (NK) cells and breast cancer cell lines in 2D and 3D cultures
BackgroundBeta-(1,3)(1,6)-D-glucan is a complex polysaccharide, which is found in the cell wall of various fungi, yeasts, bacteria, algae, barley,...
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Immunogenetics of Cancer
The influence of genes in cancer development shows different intensities, and it is mediated by diverse mechanisms. It is well known that some cancer...
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The war between the immune system and the tumor - using immune biomarkers as tracers
Nowadays, immunotherapy is one of the most promising anti-tumor therapeutic strategy. Specifically, immune-related targets can be used to predict the...
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Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML)
BackgroundKIR/HLA mismatch in hematopoietic stem cell transplantation (HSCT), particularly in patients with acute myeloid leukemia (AML), was related...
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Bone marrow infiltrated natural killer cells predicted the anti-leukemia activity of MCL1 or BCL2 inhibitors in acute myeloid leukemia
Acute myeloid leukemia (AML) is still incurable due to its heterogeneity and complexity of tumor microenvironment. It is imperative therefore to...
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A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity
Virtual memory T (T VM ) cells are a T cell subtype with a memory phenotype but no prior exposure to foreign antigen. Although T VM cells have antiviral...
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Natural killer cells: a promising immunotherapy for cancer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of...
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NK cells as powerful therapeutic tool in cancer immunotherapy
BackgroundNatural killer (NK) cells have gained considerable attention and hold great potential for their application in tumor immunotherapy. This is...
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Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications
Viruses pose a constant threat to human well-being, necessitating the immune system to develop robust defenses. Natural killer (NK) cells, which play...
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Immune reaction and regulation in transplantation based on pluripotent stem cell technology
The development of pluripotent stem cell (PSC)-based technologies provides us a new therapeutic approach that generates grafts for transplantation....
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Immuno-onco-metabolism and Therapeutic Resistance
Cancer is a complex succession of disease progressively associated with uncontrolled growth and capability of cells eluding the body’s natural...
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Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria
Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and...
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Natural killer group 2D receptor and its ligands in cancer immune escape
The immune system plays important roles in tumor development. According to the immune-editing theory, immune escape is the key to tumor survival, and...
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The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the host through killing of infected, foreign, stressed or...
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Effect of cytokines on NK cell activity and activating receptor expression in high-risk cutaneous melanoma patients
Objective: Stage II melanoma patients have high risk for regional and distant metastases and may benefit from novel therapeutic strategies. To...
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Sestrins induce natural killer function in senescent-like CD8+ T cells
Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8 + T cell compartment, aging...
