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Japanese Encephalitis Virus-Infected Cells
RNA virus infections have been a leading cause of pandemics. Aided by global warming and increased connectivity, their threat is likely to increase...
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Melatonin inhibits Japanese encephalitis virus replication and neurotoxicity via calcineurin-autophagy pathways
BackgroundJapanese encephalitis virus (JEV) is a mosquito-borne flavivirus that has no specific treatment except for supportive medical care. JEV is...
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Role of inflammatory cytokine burst in neuro-invasion of Japanese Encephalitis virus infection: an immunotherapeutic approaches
Japanese Encephalitis remains a significant global health concern, contributing to millions of deaths annually worldwide. Microglial cells, as key...
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The mutation of Japanese encephalitis virus envelope protein residue 389 attenuates viral neuroinvasiveness
The envelope (E) protein of the Japanese encephalitis virus (JEV) is a key protein for virus infection and adsorption of host cells, which determines...
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Vector competence of Swedish Culex pipiens mosquitoes for Japanese encephalitis virus
BackgroundJapanese encephalitis virus (JEV) is an emerging mosquito-borne Orthoflavivirus that poses a significant public health risk in many...
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Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak
Human infections with the Japanese encephalitis virus (JEV) are a leading cause of viral encephalitis. An unprecedented outbreak of JEV genotype 4...
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H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Histone methylation is an important epigenetic modification that affects various biological processes, including the inflammatory response. In this...
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Viral inhibitory potential of hyoscyamine in Japanese encephalitis virus–infected embryonated chicken eggs involving multiple signaling pathways
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis worldwide. The emergence of new genotypes of the virus and a high rate...
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Nucleotide at position 66 of NS2A in Japanese encephalitis virus is associated with the virulence and proliferation of virus
Most wild strains of Japanese encephalitis virus (JEV) produce NS1’ protein, which plays an important role in viral infection and immune escape. The...
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Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV...
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Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells
BackgroundPromyelocytic leukemia protein (PML) is a primary component of PML nuclear bodies (PML-NBs). PML and PML-NBs play critical roles in...
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N6-methyladenosine modification positively regulate Japanese encephalitis virus replication
N6-methyladenosine (m6A) is present in diverse viral RNA and plays important regulatory roles in virus replication and host antiviral innate...
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Fighting Dengue, Chikungunya, and Japanese Encephalitis
My arbovirus career occurred in four stages, roughly 15 years each: US Army Medical Corps, University of Hawaii School of Medicine, Rockefeller...
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Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway
Japanese encephalitis virus (JEV) infection can cause brain tissue lesions characterized by neuronal death, and apoptosis is involved in JEV-induced...
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The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report
BackgroundThe presentation of Guillain–Barré syndrome (GBS) caused by Japanese encephalitis virus (JEV) is uncommon, although clusters of GBS cases...
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Accidental acquisition of a rescued Japanese encephalitis virus with unspliced introns in the viral genome when using an intron-based stabilization approach
The intron-based stabilization approach is a very useful strategy for construction of stable flavivirus infectious clones. SA 14 -14-2 is a highly...
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Autophagy inhibitors alleviate Japanese encephalitis virus-induced cerebral inflammation in mice
Japanese encephalitis (JE) is a zoonotic epidemic disease caused by Japanese encephalitis virus (JEV), and currently, no medicines are available to...
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Genotypic characterization of Japanese encephalitis virus circulating in swine population of India: Genotype-III still in dominance
Swine is considered as a suitable sentinel to predict Japanese encephalitis virus (JEV) outbreaks in humans. The present study was undertaken to...
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YWHAH, a member of 14-3-3 family proteins, and PSME2, the proteasome activator subunit 2, are key host factors of Japanese encephalitis virus infection
BackgroundHost response to virus infection is key to the effective control and eventual elimination of viruses or infected cells; however, the...
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Japanese Encephalitis Virus Infection Causes an Imbalance in the Activation of Mitochondrial Fusion/Fission Genes and Triggers the Activation of NOX2-mediated Oxidative Stress and Neuronal Cell Death
Mitochondria dysfunction may be an important contributor to Japanese encephalitis (JE) viral infection disease pathogenesis. In the current study, we...
