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Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses
Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs) proinflammatory...
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Pharmacological Effects on Intestinal Functions
Laxatives of the sennoside type act mainly by acceleration of large intestine transit and inhibition of fluid absorption in the colon (Leng-Peschlow...
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Genomic differences in the background of different severity in juvenile-onset respiratory papillomatoses associated with human papillomavirus type 11
This study aimed to compare complete genome sequences of human papillomavirus (HPV) type 11 from two solitary papillomas (considered minimally...
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Pharmacological Effects on Intestinal Functions
Laxatives of the sennoside type act mainly by acceleration of large intestine transit and inhibition of fluid absorption in the colon (Leng-Peschlow...
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Neuroprotective Strategies in Hippocampal Neurodegeneration Induced by the Neurotoxicant Trimethyltin
The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively...
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An update on spinal cord injury research
Spinal cord injury (SCI) can have a range of debilitating effects and permanently alter the capabilities and quality of life of survivors. The first...
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The Measles Virus NTAIL-XD Complex: An Illustrative Example of Fuzziness
In this chapter, I focus on the biochemical and structural characterization of the complex between the intrinsically disordered C-terminal domain of...
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Renal System in Safety Pharmacology
If a metabolic end product or protein is small enough to be filtered at the glomerulus and is neither extensively reabsorbed or secreted, the...
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Sigma receptors as a pharmacological target for neuroprotectors. New horizons of pharmacotherapy of Parkinson disease
In this review, we analyzed the possibility of using ligands of sigma receptors in the pharmacotherapy of Parkinson disease. We reviewed the...
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Sphingolipid Metabolism and Analysis in Metabolic Disease
Sphingolipids are an important class of structural and signaling molecules within the cell. As sphingolipids have been implicated in the development...
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Sphingolipids and Cardiovascular Diseases: Lipoprotein Metabolism, Atherosclerosis and Cardiomyopathy
Heart disease is widely believed to develop from two pathological processes. Circulating lipoproteins containing the nondegradable lipid,...
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Volume 6 Indexes
This index lists all 3367 normalized pharmacological activity terms appeared in the encyclopedia in alphabetical order and a number code sequence of...
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Major Intrinsic Proteins in Biomimetic Membranes
Biological membranes define the structural and functional boundaries in living cells and their organelles. The integrity of the...
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Bistable dynamics of cardiac cell models coupled by dynamic gap junctions linked to Cardiac Memory
In an earlier study, we suggested that adaptive gap junctions (GJs) might be a basis of cardiac memory, a phenomenon which refers to persistent...
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Staging mammography nonadherent women: A qualitative study
Background . Few studies have related stages of mammography screening nonadherence with the rationale used by overdue women. Methods . We used a...
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Schizopsychotic symptom-profiles and biomarkers: Beacons in diagnostic labyrinths
Several avenues of investigation through which the ‘labyrinths’ of schizopsychotic diagnosis may be examined, are offered by the consideration of the...
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σ Receptors and Gastrointestinal Function
The properties reported in this chapter for σ ligands are in agreement with the localization of σ receptors that has been described in the...