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Dopamine and Gastrointestinal Motility
Dopamine (DA) plays an important role in regulating gastrointestinal (GI) motility function, from the esophagus to the colon. In this chapter, we...
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Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders
Gastrointestinal (GI) disorders, which extend from the esophagus to the anus, are the most common diseases of the GI tract. Among these disorders,...
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Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease
PurposeDual antiplatelet therapy with aspirin and clopidogrel is commonly used for coronary artery disease (CAD) patients undergoing percutaneous...
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Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
This is an overview of the metabolic reactions of drugs, natural products, physiological compounds, and other (general) chemicals catalyzed by flavin...
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Dopamine and Gastrointestinal Mucosa Function
The mucosa layer of the gastrointestinal (GI) tract maintains structural integrity, which is essential for kee** internal balance of fluids,...
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Circadian Clock and Non-CYP Phase I Metabolism
Circadian rhythms in drug metabolism by non-CYP phase I enzymes (i.e., MAOs) have been recognized since 1970s. The profound effects of the circadian...
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Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity
In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 diverse chemicals estimated by...
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Oral Controlled Release Systems: Current Strategies and Challenges
Oral drug delivery route is the widely favored and adaptable for all as it is endowed with a maximum surface area when compared to the other routes...
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Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers
PurposeItopride is an effective gastroprokinetic agent mainly used for the treatment of functional dyspepsia. Flavin-containing monooxygenase 3 ( FMO3 ...
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Development of Novel High Density Gastroretentive Multiparticulate Pulsatile Tablet of Clopidogrel Bisulfate Using Quality by Design Approach
Myocardial infarction, i.e., heart attack, is a fatal condition which is on the increase all over the world. It is reported that a large number of...
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Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors
Dopamine (DA) acts as gut motility modulator, via D1- and D2-like receptors, but its effective role is far from being clear. Since alterations of the...
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Stability-Indicating Spectrofluorimetric Method for Determination of Itopride Hydrochloride in Raw Material and Pharmaceutical Formulations
A simple, sensitive and rapid spectrofluorimetric method for determination of itopride hydrochloride in raw material and tablets has been developed....
