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Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications
Because of CO’s known endogenous signaling roles and its demonstrated pharmacological activity at low and safe concentrations, there is considerable...
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Abnormal Porphyrin Metabolism in Autism Spectrum Disorder and Therapeutic Implications
Autism spectrum disorder (ASD) is a mosaic of neurodevelopmental conditions composed of early-onset social interaction and communication deficits,...
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Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a broad spectrum of symptoms and prognoses. Effective therapy requires...
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The Interplay between Iron and Oxidative Stress in Brain Neurodegenerative Diseases
This chapter reviews the recent introductory of the micronutrient iron and its association with brain degenerative diseases and oxidative stress. The...
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Iron accumulation and its impact on osteoporotic fractures in postmenopausal women
Postmenopausal osteoporosis is a kind of degenerative disease, also described as “invisible killer.” Estrogen is generally considered as the key...
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Naked Eye Chemosensor and In Vivo Chelating Activity of Iron (III) By Bromopyridine Quinoxaline (BPQ)
A wide variety of medical, biomedical, and industrial applications has been reported for quinoxalines derivatives. In this work, a novel quinoxaline...
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Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism
Binge eating disorder (BED) is the most common eating disorder, yet its genetic architecture remains largely unknown. Studying BED is challenging...
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Exploiting the Achilles’ Heel of Iron Dependence in Antibiotic Resistant Bacteria with New Antimicrobial Iron Withdrawal Agents
Pathogenic microorganisms including bacteria and fungi have irreplaceable needs for iron as critically needed for the activities of a wide array of...
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Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments
BackgroundSeveral circumstances such as accidents, surgery, traumatic hemorrhagic shock, and other causalities cause major blood loss. Allogenic...
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Oligomerization of β-Like DNA Polymerases in the Presence of Fe2+ Ions
This work presents data on the relationship between the oligomeric state and catalytic activity of β-like DNA polymerases isolated from three cancer...
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Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious...
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Why is Babesia not killed by artemisinin like Plasmodium?
Babesia spp. are intraerythrocytic apicomplexans that digest and utilize red blood cells in a similar way to intraerythrocytic Plasmodium spp., but...
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Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Ischemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important...
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Sevoflurane Exposure Induces Neuronal Cell Ferroptosis Initiated by Increase of Intracellular Hydrogen Peroxide in the Develo** Brain via ER Stress ATF3 Activation
Neuronal cell death is acknowledged as the primary pathological basis underlying developmental neurotoxicity in response to sevoflurane exposure, but...
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Genomic and transcriptomic evidence of light-sensing, porphyrin biosynthesis, Calvin-Benson-Bassham cycle, and urea production in Bathyarchaeota
BackgroundBathyarchaeota, a newly proposed archaeal phylum, is considered as an important driver of the global carbon cycle. However, due to the...
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Identification of osteoporosis ferroptosis-related markers and potential therapeutic compounds based on bioinformatics methods and molecular docking technology
Research background and purposeOsteoporosis (OP) is one of the most common bone diseases worldwide, characterized by low bone mineral density and...
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Theranostics Nanomaterials for Safe Cancer Treatment
The current advancement in diagnostic research by implementing nanotechnology encourages researchers worldwide to focus towards new possibilities of...