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Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis
BackgroundChemoresistance is the main reason for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Thus, there is an urgent need to...
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A collaborative study of the impact of N-nitrosamines presence and ARB recall on ARB utilization – results from IQVIA™ Disease Analyzer Germany
PurposeRegulators are increasingly concerned with the impact of recalls on drug adherence. In 2018, N-nitrosamines impurities were detected in...
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Understanding the Oral Absorption of Irbesartan Using Biorelevant Dissolution Testing and PBPK Modeling
Poorly soluble weak bases form a significant proportion of the drugs available in the market thereby making it imperative to understand their...
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Pleiotropic effects of AT-1 receptor antagonists in hypoxia induced by cardiac ischaemia
The renin–angiotensin system (RAS) plays a crucial role and coordinates multiple body functions through its hormonal mechanism. The RAS is supported...
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Evaluation of Piperine as Natural Coformer for Eutectics Preparation of Drugs Used in the Treatment of Cardiovascular Diseases
Piperine (PIP) was evaluated as a natural coformer in the preparation of multicomponent organic materials for enhancing solubility and dissolution...
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Highly Soluble Glimepiride and Irbesartan Co-amorphous Formulation with Potential Application in Combination Therapy
One-third of the population of the USA suffers from metabolic syndrome (MetS). Treatment of patients with MetS regularly includes drugs prescribed...
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Discovery of SARS-CoV-2 Antiviral Drugs Through Large-Scale Virtual Screening of FDA-Approved Drugs
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent responsible for the viral pneumonia outbreak of coronavirus...
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Irbesartan suppresses cardiac toxicity induced by doxorubicin via regulating the p38-MAPK/NF-κB and TGF-β1 pathways
Doxorubicin (DOX) so far continues to be one of the most potent and effective anticancer drugs. Therefore, it is still needed to search for a safe...
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Erythropoietin in the Treatment of Anaemia
Anaemia is a prevalent clinical presentation in individuals suffering from chronic kidney disease (CKD). This issue is linked to an elevated...
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Drug-Excipient Compatibility Study Through a Novel Vial-in-Vial Experimental Setup: A Benchmark Study
Drug-excipient compatibility study (DECS) is one of the critical steps during pre-formulation studies to select the appropriate excipient to obtain a...
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Renin Angiotensin System Activity in Different Cancers: Mechanistic Insight and Preclinical Studies
The Renin Angiotensin System (RAS) is maintain arterial blood pressure as well as fluid and electrolyte balance in human body. In recent there...
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Renin-Angiotensin System: A Potential Therapeutic Target for Colorectal Cancer
The Renin-Angiotensin System (RAS) is associated with regulation of blood pressure, electrolyte balance, and hemostasis. It is implicated in cancer...
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The Renin-Angiotensin System and Cancer
The renin-angiotensin system (RAS), classically known for its role in cardiovascular homeostasis, is increasingly recognized to be dysregulated in...
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Repaglinide-irbesartan drug interaction: effects of SLCO1B1 polymorphism on repaglinide pharmacokinetics and pharmacodynamics in Chinese population
PurposeOn account of the potential inhibition of OATP1B1 ( organic anion transporting polypeptide ) by angiotensin II receptor blockers (ARBs) and the...
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Stereolithography (SLA) in Pharmaceuticals
Commercial stereolithography (SLA) 3D printing has been around for over three decades. However, only recently the technology has been employed in...
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Renin-Angiotensin System in Hematological Malignancies
The regular functioning of the human body is the result of interactions between numerous organs and biological systems, with the Renin-Angiotensin...
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Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma
BackgroundResearch studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS)...
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Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient
ObjectivesTo assess the impact of prior chronic treatment with angiotensin-converting enzyme inhibitors (ACEIs)/ angiotensin-receptor blockers...
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Incidence, characteristics, and risk factors of drug-associated muscle adverse reaction: a retrospective real-world study of inpatients
ObjectiveTo analyze the clinical characteristics, incidence, and distribution of drug-associated muscle adverse reactions (DAMAR) in real-world...
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Relationship between antihypertensive drug use and number of people with high blood pressure in FY 2018: a descriptive epidemiological study based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan open data
BackgroundIn most countries barring Japan, antihypertensive drug use has been reported using the defined daily doses/1000 inhabitants/day (DID)....
